摘要
目的介绍和比较医学实验设计中不同的样本含量估算方法。方法以磷酸酰肌醇-3激酶(PI3K)抑制剂对小鼠气道炎症影响的实验研究为例,运用不同方法计算样本含量。结果公式法计算需12只,PASS软件Simple法计算需8只,Stata软件计算需10只,验算其检验效能:1-β>0.9。结论 3种不同方法估算的样本含量都是合理有效的,实验研究人员可以以多种计算结果为依据,分析实验研究性质,综合考虑研究成本、可行性与伦理学要求对样本含量的影响,确定合适的样本数。
Objective To introduce and compare the different estimation methods of sample size in the medical experiment de- sign. Methods Taking the experimental study on the influence of PI3K inhibitor on respiratory tract inflammation in mouse. Results The formula method estimation needed 12 mice,while the PASS software Simple method needed 8 mice, and the stata software method needed 10 mice. The power of test was checked： 1-~0.9. Conclusion The sample size estimated by 3 different kinds of method is rational and effective. The experimental researchers can take the multiple calculated results as the basis to analyze the property of experimental study,comprehensively consider the influence of the research costs, feasibility and ethics requirements on the sample size and to determine the most appropriate sample number.
出处
《国际检验医学杂志》
CAS
2015年第9期1193-1194,1197,共3页
International Journal of Laboratory Medicine
基金
广东省科技计划项目(73092)
广州市医药卫生科技资助项目(2007-YB-026)
