摘要
目的观察短程甲基强的松冲击疗法加干扰素治疗小儿病毒性脑炎的疗效。方法收集小儿病毒性脑炎患儿34例,随机分对照组15例和观察组19例。对照组采用干扰素治疗,观察组采用短程甲基强的松冲击疗法加干扰素治疗。比较2组患儿临床症状改善时间及疗效。结果观察组发热、抽搐、脑膜刺激征、病理征、意识障碍、颅内高压的恢复时间均显著短于对照组(P<0.05)。观察组总有效率94.74%,显著高于对照组的60.00%(P<0.05)。结论短程甲基强的松冲击疗法加干扰素治疗小儿病毒性脑炎能有效缩短临床症状改善时间并提高疗效。
Objective To observe the effect of short methylprednisolone pulse therapy combined with interferon in the treatment of pediatric viral encephalitis .Methods 34 cases of children with viral encephalitis were selected and were randomly divided into two groups：the control group（n=15） and the observation group（n=19） .The control group was treated with in‐terferon treatment ,and the observation group was treated with methylprednisolone pulse therapy loaded with interferon treat‐ment .The time of the clinical symptoms improvement and differences of efficacy between the two groups were compared .Re‐sults The time of fever ,convulsions ,meningeal irritation （Kernig sign ,Brudzinski sign） ,pathologic reflex（Babinski sign） , unconsciousness ,the recovery of intracranial hypertension were significantly shorter than the control group （P〈0 .05） .The total efficiency rate in the observation group was up to 94 .74% ,which was significantly higher than 60 .00% of the control group ,and the inefficiency rate was significantly lower than the control group （P〈0 .05） .Conclusion On the basis of inter‐feron treatment ,loaded with short methylprednisolone pulse therapy can effectively reduce the time of the clinical symptoms improvement and efficacy .
出处
《中国实用神经疾病杂志》
2015年第5期36-37,共2页
Chinese Journal of Practical Nervous Diseases
关键词
小儿病毒性脑炎
甲基强的松冲击疗法
干扰素
Children with viral encephalitis
Methylprednisolone pulse therapy
Interferon
