摘要
目的：探讨左炔诺孕酮宫内缓释系统治疗功能性子宫出血（简称功血）及子宫内膜增生过长的疗效。方法对年龄31~50岁确诊为功血并有子宫内膜增生过长的72例患者，放置LNG－IUS进行治疗，对比治疗前后月经量、月经周期、血红蛋白水平、子宫内膜厚度等指标。结果放置LNG－IUS后，患者的月经量显著性减少，放置1年左右后降至（9±3）mL，子宫内膜厚度明显变小，由放置LNG－IUS前（0.76±0.15）cm降至（0.39±0.08）cm；放置6个月后，子宫内膜增生过长得到改善；同时，放置LNG－IUS后患者血红蛋白水平呈上升趋势，6个月后恢复至正常状态，差异具有统计学意义（ P＜0.05），但放置前后月经周期间的差异无显著性。结论 LNG－IUS能有效治疗功血，减少月经量，对子宫内膜增生过长也有疗效，值得推广。
Objective To investigate the clinical effect of levonorgestre-releasing intrauterine system （ LNG-IUS ） in the treatment of dysfunctional uterine bleeding and its influence on endometrial hyperplasia. Methods 72 cases of dysfunctional uterine bleeding and endometrial hyperplasia aged 31-50 years old were treated with LNG-IUS. The indexes of the menstrual amount, menstrual cycle, hemoglobin levels and endometrial thickness during treatment were compared with those before treatment. Results After the treatment of LNG-IUS, the menstrual amount was significantly decreased and reduced to （ 9 ± 3 ） mL after 1-year LNG-IUS treatment; the en-dometrial thickness was diminished from （ 0. 76 ± 0. 15 ） cm to （ 0. 39 ± 0. 08 ） cm, endometrial hyperplasia was improved after 6-month LNG-IUS treatment. At the same time, the hemoglobin levels showed the increasing trend and recovered to normal status after 6-momth treatment, the differences of the data between before and after treatment were statistically significant （ P 〈 0. 05 ） . But the differ-ence of the menstrual cycle had no statistically significant difference between before and after treatment. Conclusion LNG-IUS can effectively treat dysfunctional uterine bleeding, reduces the menstrual amount, also has the curative effect on endometrial hyperplasia and is worth popularizing.
出处
《中国药业》
CAS
2015年第9期97-99,共3页
China Pharmaceuticals
关键词
左炔诺孕酮宫内缓释系统
功能性子宫出血
子宫内膜增生过长
levonorgestre-releasing intrauterine system
dysfunctional uterine bleeding
endometrial hyperplasia
