摘要
目的观察益气化聚颗粒联合西药治疗代谢综合征微量白蛋白尿的临床疗效。方法将100例代谢综合征微量白蛋白尿症患者随机分为治疗组与对照组,每组50例。治疗组在常规西医治疗基础上加用益气化聚颗粒,对照组在常规西医治疗基础上加用安慰剂。两组疗程均为12周,观察微量白蛋白尿的转阴率,比较尿液相关指标(MA、UACR、24 h TP、尿转铁蛋白及尿β2微球蛋白)、形体体征指标(BMI、WHR、SBP、DBP及MAP)、血糖(FPG、2 h PPG、Hb A1c及HOMA-IR)及血脂(TC、TG、LDL、HDL)的变化情况。结果 1试验期间无脱落病例,100例受试者均完成试验研究。2治疗组、对照组转阴率分别为28.00%和10.00%;组间转阴率比较,差异有统计学意义(P<0.05)。3组间治疗后比较,MA、UACR、24 h TP及尿β2微球蛋白水平差异有统计学意义(P<0.05)。4组间治疗后比较,BMI、WHR、SBP及MAP水平差异有统计学意义(P<0.05)。5组间治疗后比较,FPG、2 h PPG、Hb A1c及HOMAIR水平差异有统计学意义(P<0.05)。6组间治疗后比较,TG水平差异有统计学意义(P<0.05)。结论益气化聚颗粒联合西药治疗代谢综合征微量白蛋白尿,可有效控制疾病的进展,提高胰岛素敏感性,减轻中心性肥胖程度。
Objective To observe the clinical efficacy of ＂Yiqi Huaju Granules＂ and western medicine for the treatment of metabolic syndrome coupled with microalbuminuria. Methods One hundred cases with were randomized into treatment group and control group, with 50 cases in each group. The treatment group was treated with western medicine and ＂Yiqi Huaju Granules＂, and the control group was treated with western medicine and placebo, with the course of 12 weeks. The negative conversion ratio of microalbuminuria was observed, and the indicators of urine （MA, UACR, 24 hTP, urinary transferring and β2 microglobulin） , signs indicators （BMI, WHR, SBP, DBP, MAP） , and blood sugar （FPG, 2 bPPG, HbAle, HOMA-IR） and blood fat （TC, TG, LDL, HDL） were compared. Results ①All of the 100 subjects completed the clinical study. ②The total negative conversion rate of MA was 28.00% in the treatment group and was 10.00% in the control group, with a difference between the two groups （P 〈 0.05 ）. ③Afier treatment, there were significant differences in the levels of MA, UACR, 24 hTP and urinary 132 microglobulin between the two groups （P 〈 0.05）.④Afier treatment, there were significant differences in the levels of BMI, WHR, SBP and MAP between the two groups （ P 〈 0.05）.⑤After treatment, there were significant differences in the levels of FPG, 2 hPPG, HbA1 c and HOMA-IR between the two groups （ P 〈 0.05 ）. ⑥Afier treatment, there were significant differences in TG level between the two groups （ P 〈0. 05 ）. Conclusion Combined ＂Yiqi Huaju Granules＂ and western medicine is effective to control the progress of the disease, enhance the insulin sensitivity and reduce central obesity in metabolic syndrome coupled with microalbuminuria.
出处
《上海中医药杂志》
2015年第5期36-40,共5页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金青年基金项目(81001574)
上海市中西医结合学会科研基金项目(zxy Q-1245)
上海市中医临床优势专科建设项目(ZYSNKD-YL-YSZK013)
上海市科委医学引导类科技资助项目(12401905100)
上海市名老中医学术经验研究工作室建设项目(ZYSNXD-CC-MZY034)
上海市第六人民医院院级科研基金项目(YNLC201430)
