摘要
目的研究冠心病患者心血管意外和凝血功能相关性。方法从2013年4月到2014年1月,选取我院的96例冠心病患者进行回顾性分析,均采用冠脉CT检查心血管凝血情况,分析了解凝血功能与心血管意外的相关性。结果 96例冠心病患者进行了随访,其中有16例患者因心血管意外而死亡,其中有34名患者发生心血管意外但并不致死,死亡以及非致死性心血管意外患者的调查中血浆高密度脂蛋白浓度较低,同时C反应蛋白,白细胞介素浓度较高;心血管意外死亡组患者的凝血功能指标显著高于比非致死性心血管意外组,而非致死性心血管意外组又显著高于无心血管意外组,组间的比较差异具有统计学意义(P<0.05);凝血因子水平和其他心血管危险因素的关系v WF、PAP、浓度随着年龄的增长而升高,纤维蛋白原、TAT水平与年龄无关,其他凝血功能参数和心血管影响因素的关系。结论冠心病患者心血管意外与高凝血状态有一定的关系,为了减少心血管意外的发生。
Objective To study the correlation analysis of cardiovascular accidents and blood coagulation function in patients with coronary heart disease（ CHD）. Methods From April 2013 to January 2014,selected from 96 cases of coronary heart disease patients in our hospital,and they were retrospectively analyzed,both by coronary angiography examination of cardiovascular blood coagulation,analyzed and understood the correlation of blood coagulation function and cardiovascular accident. Results 96 cases of coronary heart disease patients who were followed up,there are 16 patients died when the cardiovascular accident,there were 34 patients with cardiovascular accident but not death,death,nonfatal cardiovascular accident investigation in the patients with plasma high-density lipoprotein cholesterol（ hdl-c） concentration was low,at the same time c-reactive protein,interleukin higher levels; Index of blood coagulation function in patients with cardiovascular death group was significantly higher than than nonfatal cardiovascular accident group,and nonfatal cardiovascular accident group was significantly higher than that without cardiovascular accident,the comparison of differences between groups with statistical significance（ P 〈 0. 05）; Clotting factor the relations,and other cardiovascular risk factors v WF,PAP,concentration with increasing age,level of fibrinogen,TAT has nothing to do with age,other blood coagulation function relationship and the influence factor of cardiovascular parameters. Conclusion Patients with coronary heart disease,cardiovascular accident have a certain relationship with high coagulation state,in order to reduce the occurrence of cardiovascular accident,need to be timely prevention and treatment,and anticoagulant therapy to prevent and correct the high coagulation state is prevention,commonly used in the treatment of cardiovascular accident means,is worth further promotion in the clinical practice.
出处
《血栓与止血学》
2015年第2期77-79,共3页
Chinese Journal of Thrombosis and Hemostasis
关键词
冠心病
心血管意外
凝血功能
Coronary heart disease
Cardiovascular accidents
Blood coagulation function
