摘要
目的观察益肾安宫方联合黄体酮注射液治疗先兆流产的临床疗效。方法将100例先兆流产患者随机分为治疗组和对照组各50例。对照组给予肌肉注射黄体酮注射液40 mg,每天1次。治疗组在对照组基础上配合中医辨证施治,分为肾虚血热型及脾肾两虚型,分别给予益肾安宫Ⅰ号方及益肾安宫Ⅱ号方,每日1剂。两组均以7天为1个疗程,共3个疗程。两组均于治疗前及治疗1、2、3周后测定血清绒毛膜促性腺激素(β-HCG)、孕酮(P)、雌二醇(E2)水平,比较两组治疗前后中医证候积分。治疗后评价综合疗效和证候疗效,比较治疗组不同年龄、不同自然流产史、不同孕周患者临床综合疗效。结果治疗组和对照组综合疗效分别为88%、72%,治疗组明显优于对照组(P<0.05)。两组治疗后中医证候积分均较治疗前明显降低(P<0.01);治疗后治疗组中医证候积分明显低于对照组(P<0.05)。两组患者治疗1、2、3周后血清β-HCG、E2水平均较治疗前明显上升(P<0.01),治疗组治疗1、2、3周后血清P水平较治疗前明显上升(P<0.01或P<0.05),对照组治疗2、3周后血清P水平较治疗前明显上升(P<0.01);治疗组治疗1、2、3周后血清E2水平明显高于对照组(P<0.01)。治疗组不同年龄段、不同自然流产史、不同孕周患者综合疗效总有效率比较,差异均无统计学意义(P>0.05)。结论益肾安宫方联合黄体酮注射液治疗先兆流产疗效确切,且不受患者年龄、自然流产史、孕周因素的影响,并能明显改善中医症状,升高血清E2水平。
Objective To observe the clinical effect the treatment with Yishen Angong Formula combined with progesterone injection on threatened abortion. Methods Totally 100 cases of threatened abortion patients were randomly divided into treatment group and control group, with 50 cases in each group. In the control group, patients were given intramuscular injection of progesterone injection 40 mg, 1 time per day. According to TCM syndrome differentiation, patients in the treatment group were divided into kidney deficiency and blood heat pattern and the kidney and spleen deficiency pattern, and were given prescription No. 1 and No. 2 of Yishen Angong Formula respectively, one dose per day. For the two groups, set 7 days as one course, and totally treated with 3 courses. The levels of serum chorionic gonadotropin （beta-HCG）, progesterone （P）, estradiol （E2 ） were tested in both groups before treat-ment, and 1, 2, 3 weeks after treatment. The TCM syndrome score will be compared in two groups before and after treatment. After treatment, evaluated the comprehensive efficacy and syndrome efficacy, then evaluated the clinical comprehensive therapeutic effect in the treatment group among patients with different age, different history of natural abortion and different gestational weeks. Results In the treatment group and the control group, the total effective rates of the clinical curative effect are respectively 88% and 72%, and the treatment group was significantly better than the control group （ P 〈 0. 05 ）. After treatment, the TCM syndrome score of the two groups was significantly lower than those before treatment （P 〈0. 01 ） ; and after treatment, TCM syndrome score of the control group was significantly lower than the control group （P levels of the patients in both groups were 〈 0.05）. One, two, three weeks after the treatment, the serum -HCG, E2 significantly increased compared with those before treatment （P 〈 0.01 ）. In the treatment group, one, two, three weeks after the treatment, the
出处
《中医杂志》
CSCD
北大核心
2015年第9期773-777,共5页
Journal of Traditional Chinese Medicine
基金
浙江省中医药科技计划(2013ZB093)
关键词
先兆流产
益肾安宫方
绒毛膜促性腺激素
孕酮
雌二醇
threatened abortion
Yishen Angong Formula
chorionie gonadotropin
progesterone
oestradiol
