摘要
目的探讨米索前列醇片经阴道给药,用于无痛人工流产术的临床疗效。方法选择于我院妇产科门诊就诊,并自愿要求实施无痛人工流产术的患者266例,随机分为观察组和对照组。观察组术前予以米索前列醇片压碎后阴道给药,根据患者孕期、孕史情况,严格控制药物剂量及给药时间,按孕期不同选取所需规格吸管及钳夹术;对照组则不予使用米索前列醇片,余同观察组。评价两组患者术中宫颈扩张情况、手术时间、术中出血量以及手术并发症。结果手术完成情况:治疗组完成130例(97.74%),对照组完成133例(100.00%)。在宫颈扩张方面,观察组宫颈扩张情况优于对照组(P<0.05)。在手术时间方面,观察组手术时间明显短于对照组(P<0.05)。在术中出血量方面,观察组术中出血量明显少于对照组(P<0.05)。在安全性方面,治疗组中5例、对照组中8例患者出现皮肤潮红等一过性不良反应,无手术并发症。结论米索前列醇片应用于人工流产术有利于术中宫颈扩张,并能缩短手术时间,具有较好的安全性。
Objective To explore clinical efficacy of vaginal misoprostol for painless artificial abortion. Methods A total number of 266 cases who voluntarily requested painless artificial abortion were recruited. The patients were randomized to either treatment or control group. In the treatment group, the patients were given crushed misoprostol via vagina with different dosages and duration of drug according to different gestation stages after intravenous anesthesia with propofol. Then the proper size of suction tube and clamp were chosen. In the control group,the process of operation was the same as the treatment group except for that misoprostol was not used. The intraoperative cervical dilatation,operation time,intraoperatve blood loss and postoperative complications in two groups were evaluated of patients. Results The operation completion: 130 cases in treatment group (97. 74%) and 133 cases in control group (100. 00%). The difference of cervical dilatation in the two groups was significant (P〈0.05). And t test showed that the length of operation time was significantly reduced in the treatment group compared with the controll group (P〈0.05). In the aspect of intraoperative blood loss, the treatment group was obviously less than the control group and the difference was statistically significant (P〈0.05). In terms of safety,operations went smoothly in both groups, 5 cases in the treatment group and 8 cases in control group with transient adverse reactions such as skin flush and so on. No surgical complications were evident. Conclusion Misoprostol could simplify the course of uterine aspiration, shorten the duration of operation, and improve the safety of anesthesia by softening and dilating the cervix.
出处
《成都医学院学报》
CAS
2015年第2期216-218,共3页
Journal of Chengdu Medical College
关键词
米索前列醇片
阴道给药
无痛人工流产术
Misoprostol
Intravaginal administration
Painless artifical abortion