摘要
目的：探讨视黄醇结合蛋白（RBP）和血清胱抑素C（CysC）以及同型半胱氨酸（Hcy）在糖尿病肾损伤患者中的检测意义。方法随机选取2013年3月~2014年12月117例2型糖尿病患者，根据尿蛋白定量分为A组（尿蛋白〈150 mg/24 h）和B组（尿蛋白为150~300 mg/24 h）。选择同期正常体检者56例作为对照组。比较3组患者的RBP、CysC、Hcy水平变化。结果 A、B组患者的RBP、CysC、Hcy水平显著高于对照组（均P〈0.05），随着病情进展，A组患者的RBP、CysC、Hcy水平显著高于B组（均P〈0.05）。 A、B组RBP、CysC、Hcy联合检测与RBP、CysC、Hcy各项单独检测比较，差异有统计学意义（均P〈0.05）。结论糖尿病患者定期检测RBP、CysC、Hcy，对2型糖尿病患者肾小球滤过功能损害的早期诊断和降低该疾病的发生具有重要意义。
Objective To explore the value for detection of retinol binding protein （RBP）,serum cystatin C （CysC） and homocysteine （Hcy） in patients with diabetic renal injury. Methods 117 patients with type 2 diabetes in our hospital from March 2013 to December 2014 were randomly selected,according to the quantity of urinary protein,the patients were divided into group A （urine protein was less than 150 mg/24 h） and group B （urine protein was 150-300 mg/24 h）. 56 normal physical examination human during the same period were selected as control group.The level change of RBP, CysC and Hcy among three groups was compared. Results The level of RBP,CysC and Hcy in group A and group B was higher than that in control group（P〈0.05）.With the progress of the disease,the level of RBP,CysC and Hcy in group A was higher than that in group B （P〈0.05）.There was significant difference about RBP,CysC,Hcy combination detection in group A or group B compared with RBP,CysC,Hcy detection separately in group A or group B （P〈0.05）. Conclusion Regular monitoring of RBP,CysC and Hcy for diabetic patients has important significance in early diagnosis of glomeru-lar filtration function damage in type 2 diabetic patients and reducing the occurrence of the disease.
出处
《中国当代医药》
2015年第12期133-135,共3页
China Modern Medicine
