摘要
目的通过对老年舒张性心力衰竭患者血清脂联素及骨桥蛋白含量测定,分析其在舒张性心衰的相关性。方法选用DHF患者60例作为试验组,然后按照NYHA心功能分级分为,心功能Ⅱ级17例,心功能Ⅲ级21例,心功能Ⅳ级22例,给予相应治疗3个月后进行随访,另选择同期我院门诊体检健康者36例作为对照组,试验组于治疗前和随访时,对照组于体检时和随访时检测血清脂联素和骨桥蛋白,采用酶联免疫吸附法测定60例舒张性心力衰竭患者和36例正常体检者血清中脂联素与骨桥蛋白的含量,统计学分析。结果试验组血清脂联素及骨桥蛋白含量显著高于对照组,并且随着心功能级别的增加血清脂联素及骨桥蛋白的含量升高。相关分析得出,试验组血清脂联素与骨桥蛋白浓度与心功能分级呈正相关性。结论脂联素与骨桥蛋白参与了舒张性心力衰竭的病理生理过程,有望成为心衰早期血清学标志之一。
Objectives Based on the diastolic heart failure in the elderly patients with serum adiponectin and osteopontin deter-mination, analysis of the correlation in diastolic heart failure.Methods Choose 60 patients with diastolic heart failure consist the experiment group, thenaccording to theNYHA,17patients in NYHA 2,21patients inNYHA3,22patients in NYHA 4,after given the corresponding treatment for 3 months,follow up.then select a control group consisted of 36 cases of normal physical examinees,deter-mine the adiponectin and osteopontin in serum before treatment and followed up in experimental group,control group on physical ex-amination and follow up with enzyme linked immunosorbent assay, determine the content of 60patients and 36 normal physical exami-nees,statistical analysis.Results in the experimental group, serum adiponectin and osteopontin contents were significantly higher than control group.Correlation analysis showed that serum adiponectin concentration in experimental group and the Objective：Based on the diastolic heart failure in the elderly patients with serum adiponectin and osteopontin determination, analysis of the correlation in diastolic heart failure Methods to determine the content of patients with diastolic heart failure and 18 cases of normal physical ex-aminees of adiponectin and osteopontin in serum of 20 cases with enzyme linked immunosorbent assay, statistical analysis.Results in the experimental group, serum adiponectin and osteopontin contents were significantly higher than control group.Correlation analysis showed that serum adiponectin concentration in experimental group and there was a positive correlation between opn.Conclusions Adiponectin and OPN is involved in the pathophysiological process of diastolic heart failure.Promises to be one of the early serologi-cal markers of heart failure.re was a positive correlation between opn.Conclusion： Adiponectin and OPN is involved in the patho-physiological process of diastolic heart failure.Promises to be one of the early serological mar
出处
《中国老年保健医学》
2015年第2期32-34,共3页
Chinese Journal of Geriatric Care
基金
黑龙江省教育厅科学技术研究项目(项目编号:12541828)
国家自然科学基金(81061120527
81370445
81472408)
卫生部公益性研究基金(201302008)
国家科技部十二五支撑计划(2012BAI10B01)
