摘要
目的探讨中国大陆人群慢性阻塞性肺疾病（COPD）发生的主要危险因素，为预防决策提供依据。方法应用Meta分析方法对国内8篇有关COPD发病主要危险因素的病例一对照研究结果进行定量综合分析；采用RevMan5．2进行一致性检验及合并OR值和95％CI计算，对合并OR值大于1的危险因素进行人群归因危险度百分比（PARP）计算。结果各因素合并OR（95％CD，PARP分别为：吸烟OR=2．12（1_58～2．86），PARP=28．16％；职业暴露OR=1．82（1．04～3．18），PARP=11．60％；呼吸疾病家族史OR=1．82（1．36～2．44），PARP=14．25％；煤、生物燃料OR=3．29（1．01～10．67），PARP=4l.29％；低体质量指数（BMI）OR=2．58（1．78～3．74），PARP=5．71％；低文化程度OR=1．24（1．02～1．50），PARP=12．93％；儿童时期反复呼吸道感染史OR=2．10（0．99～4．47），PARP=13．39％；被动吸烟OR=1．00（0．89～1．11）。结论吸烟、职业暴露、呼吸疾病家族史、煤及生物燃料、低BMI、文化程度低及儿童时期慢性呼吸道感染史是目前中国大陆人群COPD发病的危险因素。
Objective To explore the main risk factors related to the incidence ol chronic obstructive pulmonary Olsease （COPD） among Chinese people in mainland so as to provide the basis for the decision making on COPD prevention. Methods Eight published literatures of case-control studies on the risk factor of COPD were collected and analyzed quantitatively and synthetically by the meta analysis; the RevMan 5.2 software was adopted to perform the consistency test and calculate the pooled odds radio （OR） value and 95%CI. The risk factors with the OR value〉l were performed the calculation of population attributable risk pro- portion（PARP）. Results The pooled odds radio values,95%CI and PARP were smoking OR=2. 12（1. 58-2. 86）,PARP= 28.16 %; occupational exposure OR = 1.82 （ 1.04 - 3.18）, PARP = 11.60 % family history of respiratory disease OR = 1.82 （ 1.36 -2.44） ,PARP= 14.25% ;coal and biomass fuel for cooking and heating OR=3.29（1.01- 10.67） ,PARP=41.29%;low body mass index OR=2.58（1.78--3.74） ,PARP=5.71%.;low educational degree OR= 1.24（1.02- 1.50） ,PARP= 12.93%; history of re- current respiratory tract infection during childhood OR = 2. 10 （0. 99 - 4. 47）, PARP = 13. 39%; passitive smoking OR = 1. O0 （0.89-1.11）. Conclusion Smoking,occupational exposure, family history of respiratory disease, coal and biomass fuel for cooking and heating, low body mass index, low educational degree and history of recurrent respiratory tract infection during childhood are the risk factors influencing the incidence of COPD among Chinese people in mainland.
出处
《重庆医学》
CAS
北大核心
2015年第12期1655-1657,共3页
Chongqing medicine
基金
广西省教育厅人文社会科学基金资助项目(11512188)
