摘要
目的探讨脓毒症患者血浆瓜氨酸水平与胃肠功能障碍及SOFA评分的相关性。方法选择60例脓毒症患者,应用高效液相色谱法(HLPC)检测其第1天、第3天、第7天血浆瓜氨酸水平,并进行胃肠功能障碍评分及SOFA评分。根据患者28 d结局将患者分为存活组和死亡组。比较两组血浆瓜氨酸水平、胃肠功能障碍评分及序贯器官功能衰竭评分(sequential organ failure assessment,SOFA)评分的差异,并进行Pearson相关性分析。结果存活组患者血浆瓜氨酸水平显著高于死亡组,(P<0.05)。在两组患者中,瓜氨酸水平与患者胃肠障碍评分有显著负相关,(P<0.05),在死亡组中,瓜氨酸水平与患者SOFA评分有显著负相关(P<0.05),存活组中,瓜氨酸水平与患者SOFA评分无显著相关性,(P>0.05)。结论脓毒症患者血浆瓜氨酸水平能够反映患者的胃肠功能及预后。
Objective To studythe levels of citrulline and in sepsis patients and the correlations with the gut dysfunction score and SOFA. Methods This study include 60 sepsis patients and their levels of citrulline were detected by HLPC at 1, 3, 7 day and assess their the gut dysfunction score and SOFA scores. These patients were dived into survivor group and death group according to the prognosis at the 28 days. The relationship between citrulline level and gut dysfunction score and SOFA scores were analyzed by Pearson test. Results The level of citrulline in the survivor group was significantly higher than death group（P〈0.05）. There were negative correlationsbetween the level of citrulline and gut dysfunction score in survivor group and death group（P〈0.05）. In the death group, there was a negative correlationsbetween the level of citrulline and SOFA scores（P〈0.05） while there had no significant between the level of citrulline and SOFA scores in the survivor group（P〈0.05）.Conclusion Plasma citrulline level ofsepsis patients can reflect the gastrointestinal function and prognosis of patients.
出处
《中国医药指南》
2015年第10期1-2,共2页
Guide of China Medicine
基金
深圳市科技计划项目(编号:201203046)
