摘要
目的:探讨CHOP方案对外周T细胞淋巴瘤(PTCL)患者外周血中初始和记忆T细胞水平的变化及其临床意义。方法:采用流式细胞术检测20例PTCL患者CHOP方案化疗前后外周血中CD4+CD45RA+、CD4+CD45RO+、CD8+CD45RA+和CD8+CD45RO+T细胞的比例,分析疗效与T细胞亚群的关系。结果:PTCL患者化疗前外周血中CD4+T细胞、CD4+CD45RO+细胞的比例明显降低,CD4+CD45RA+、CD8+、CD8+CD45RO+和CD8+CD45RA+T细胞的比例均明显升高(P<0.05),而化疗后PTCL患者CD4+、CD4+CD45RO+细胞的比例较治疗前升高,CD4+CD45RA+、CD8+、CD8+CD45RO+和CD8+CD45RA+T细胞比例则较治疗前稍下降(P<0.05)。治疗前后化疗有效组的CD4+CD45RA+均明显高于化疗无效组(P<0.05)。结论:CHOP治疗对PTCL患者胸腺输出功能有一定的影响,伴有较高胸腺输出功能者对化疗效果更好。
Objective：To explore the change of initial and memory T cells in peripheral blood and their clinical significance in peripheral T cell lymphoma patients（ PTCL） before and after CHOP chemotherapy. Methods： The proportion of CD4＋CD45RA＋T cells and CD4＋CD45RO＋T cells,CD8＋CD45RA＋T cells and CD8＋CD45RO＋T cells in peripheral blood from 20 PTCL patients before and after chemotherapy was detected by flow cytometry, the relationship between curative effect and T cell subset was further analyzed. Results： Before treatment,the proportion of CD4＋and CD4＋CD45RO＋T cells in PTCL patients was significantly lower than that from the control group,while the proportion of CD4＋CD45RA＋,CD8＋,CD8＋CD45RO＋and CD8＋CD45RA＋T cells was significantly higher（ P〈0. 05）;after treatment,proportion of CD4＋,CD4＋CD45RO＋T was significantly increased,CD4＋CD45RA＋,CD8＋,CD8＋CD45RO＋,CD8＋CD45RA＋T was slightly decreased（ P〈0. 05）. Before and after treatment,higher proportion of CD4＋CD45RA＋T cells was found in response group compared with no response group. Conclusion： CHOP chemotherapy might influence the thymic output function in PTCL patients,patients with higher thymic output function may have better response to chemotherapy.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2015年第4期531-533,536,共4页
Chinese Journal of Immunology
基金
广东省科技计划(国际合作)项目(2012B050600023)
