摘要
目的评价慢性阻塞性肺疾病急性加重的诊断和治疗中降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)水平检测的临床意义。方法选取2011-03/2013-06月间来作者医院呼吸科诊治的慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者164例,通过检测稳定期(80例)与急性加重期(84例)患者的PCT以及CRP含量,评价两者对于COPD急性加重(acute chronic obstructive pulmonary disease,AECOPD)的诊断意义,同时临床根据PCT与CRP水平进行指导治疗,评价两者在COPD治疗中的指导作用。结果 AECOPD组的PCT、CRP表达水平与COPD组相比显著升高;治疗COPD后发现,两组患者的治疗有效率比较,差异无统计学意义(P>0.05);指导治疗组患者AECOPD发生率与常规治疗组相比发生率下降,但组间差异无统计学意义(P>0.05);但对于住院时间、抗菌治疗时间、二重感染率而言,指导治疗组较常规治疗组显著减少(P<0.05)。结论 PCT、CRP能够作为早期诊断AECOPD的血清学指标,同时PCT、CRP检测用于指导COPD的临床治疗,缩短了患者的住院时间,显著降低了抗菌药物的使用和二重感染的发生,值得在临床上广泛使用。
Objective To evaluate the clinical significance of C-reactive protein and procalcitonin in the diagnosis and treatment of chronic obstructive pulmonary disease （COPD）. Methods A total of 164 COPD patients were selected in respiratory department of our hospital during March 2011 to June 2013, included 84 cases in acute exacerbation period （AECOPD） and 80 cases in stable period. Through detecting the expression of procalcitonin and C-reactive protein, the clinical significance of COPD diagnosing was evaluated. Meanwhile, following the treatment guidance based on PCT and CRP levels, the guiding role of PCT and CRP in COPD treatment was accessed. Results Compared with the COPD group, the expression levels of PCT and CRP of AECOPD group were significantly higher.The efficiency of the treatment of COPE） were not significantly different between guide therapy group and conventional therapy group, the incidence of AECOPD in patients treated with guidance decreased more than that in conventional therapy group, but there was no sig- nificant difference.The duration of hospitalization,antibiotic treatment time, superinfection rates in guide treatment group were significantly reduced compared with conventional therapy group.Conclusion PCT and CRP can be used as early serological markers to diagnose AECOPD, and the dynamic detection of PCT, CRP level can be used to guide clinical treatment of COPD , shorten the duration of hospitalization, and reduce the use of antibiotics and the occurrence of dual infection.
出处
《华南国防医学杂志》
CAS
2014年第7期645-647,共3页
Military Medical Journal of South China
基金
山东省医药卫生科技发展计划项目立项计划(2013WS0337)
关键词
降钙素原
C反应蛋白
慢性阻塞性肺疾病
急性加重
Procalcitonin
C-reactive protein
Chronic obstructive pulmonary disease
Acute exacerbation
