摘要
目的探讨历代医家临床治疗老年性痴呆的中药组方配伍规律。方法以健忘、多忘、痴、呆为检索词,检索《中华医典》中相关文献,筛选方剂信息并进行标准化处理,构建数据库,通过频数分析及关联规则方法挖掘方剂的中药组成和配伍规律。结果共选出449首与治疗老年性痴呆相关的处方,涉及中药682味。方中出现频次最高的单味药为人参(192),药对为人参、远志(182),3味药物组合为茯神、人参、远志(79),4味药物组合为远志、人参、茯神、甘草(37),通过关联规则分析得出,人参-远志、人参-甘草、人参-茯神等为临床治疗老年性痴呆的方剂中常用配伍。结论历代医家治疗老年性痴呆选药以补益、安神药物为主,其配伍组合合理,具有一定代表性。
Objective To study the compatibility of TCM prescriptions of TCM practitioners of all dynasties of Alzheimer disease （AD）. Methods Amnesia, forgetting, dementia, and idiot were set as search words to retrieve relevant literature in Encyclopadia of Traditional Chinese Medicine. Prescription information was screened and standardized to build database. Frequency analysis and association rules were used to mine TCM prescriptions and compatibility rules. Results Totally 449 AD related prescriptions were selected, involving 682 Chinese medicinal herbs. The individual herb with the highest frequency was Ginseng Radix Rhizoma （192）;the herbal pair with the highest frequency was Ginseng Radix Rhizoma-Polyhalae Radix （182）;the herbal combination with 3 Chinese medicinal herbs with the highest frequency was Poria with Hostwood-Ginseng Radix Rhizoma-Polyhalae Radix （79）;the herbal combination with 4 Chinese medicinal herbs with the highest frequency was Polyhalae Radix-Ginseng Radix Rhizoma-Poria with Hostwood-Glycyrrhizae Radix et Rhizoma （37）. The results of association rules showed that Ginseng Radix Rhizoma-Polyhalae Radix, Ginseng Radix Rhizoma-Glycyrrhizae Radix et Rhizoma, and Ginseng Radix Rhizoma-Poria with Hostwood were commonly used compatibilities in AD related prescriptions. Conclusion Treatment of TCM practitioners in all dynasties for AD mainly chooses Chinese medicinal herbs with the efficacy of tonifying qi and soothing nerves. The compatibilities and combinations are reasonable and with certain representativeness.
出处
《中国中医药信息杂志》
CAS
CSCD
2015年第5期41-44,共4页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家高技术研究发展计划(2013AA093001)
教育部高等学校博士学科点专项科研基金(20123731120001)
山东省人力资源和社会保障厅博士后创新项目(201102036)
山东中医药大学大学生研究训练计划(201310441107)
关键词
老年性痴呆
用药规律
中医文献
数据挖掘
Alzheimer disease
medication rules
TCM literature
data mining
