摘要
目的探讨HPV L1壳蛋白在预测宫颈上皮内瘤变（CIN）转归中的意义。方法选择液基细胞学（TCT）结果异常且高危型HPVHC2阳性的妇女144例，同时行HPV L1壳蛋白检测及宫颈活检，病理结果为诊断的金标准，并对CIN患者进行2年的随访。结果HPV L1壳蛋白在CINI的阳性率最高（63．3％），大于CIN1I和CINⅢ组，差异有统计学意义（P〈0．01），CINII和CIN Ⅲ比较，差异未见统计学意义（P〉0．05）。CINI组中HPV L1壳蛋白阳性者和HPVL1壳蛋白阴性者的自然消退率、病变进展率比较，差异有统计学意义（P〈0．05）。CINI组中HPVL1壳蛋白预测病变进展的灵敏度为69．0％，特异度为71．4％，阳性预测值为93．5％，阴性预测值为27．8％。结论HPVL1壳蛋白在判断CINI的预后情况中有显著的意义，为临床上处理CINI上提供指导意义。
Ohjective To study the clinical value of HPV L1 capsid protein on predicting outcome of cervical intraepithelial neoplasia. Methods The HPV L1 caspid protein in cytologic specimens was detected by immunochemistry and cervical biopsy were performed in 144 patients whose HPV DNA detection Was positive and TCT detection was abnormal. All diagnosis were confirmed in histology. The patients with CIN were followed up for at least 2 years. Results The positive rate of immunostaining reaction for HPV L1 capsid protein of CIN I was 63.3%, which was higher than CIN I and CIN m （P 〈 o. Ol ）. However, the differences of positive rates of CIN ]I and CIN l]I in the two groups were not statis- tically significant（ P 〉 0. 05 ）. The spontaneous regression rate of HPV L1 positive CINI patients was higher than that of HPV L1 negative CINI patients （P 〈 0. 05 ）. The same as the progression rate （P 〈 0.05）. The sensitivity, specificity, positive predictive value and negative predictive value for the HPV L1 predicting outcome of CINI were 69.0%, 71.4%, 93.5% and 27.8%, respectively. Conclusions The value of HPV L1 in predicting outcome of CINI is significant. Immunocytochemical detection of HPV L1 capsid protein may provide guidance for treatment CINI.
出处
《中国实用医刊》
2015年第9期66-67,共2页
Chinese Journal of Practical Medicine
关键词
HPV
L1壳蛋白
宫颈上皮内瘤变
人乳头瘤病毒
HPV L1 capsid protein
Cervical intraepithelial neoplasia
Human papilloma virus
