摘要
目的探讨血浆晚期糖基化终末产物(AGEs)水平变化对肠梗阻术后患者病情评估的临床意义。方法选取2010年5月—2014年2月辽宁医学院附属第一医院胃肠外科收治的肠梗阻患者376例,其中术后未出现并发症者324例,为对照组;出现并发症者52例,为试验组,分别为感染11例,肠道功能障碍16例,血糖紊乱8例,吻合口破裂及瘘5例,急性呼吸窘迫综合征(ARDS)8例,肠系膜动脉栓塞4例。分别无菌采集患者术后第1、3、5、7、14天静脉血3 ml,采用ELISA法检测血浆AGEs水平。结果两组术后不同时间血浆AGEs水平比较,差异有统计学意义(P<0.05)。组间比较结果显示:术后第1、14天,两组血浆AGEs水平比较,差异无统计学意义(P>0.05);术后第3、5、7天,试验组血浆AGEs水平高于对照组(P<0.05)。组内比较结果显示,试验组术后第3天血浆AGEs水平高于术后第1天(P<0.05)。不同肠梗阻并发症患者术后不同时间血浆AGEs水平比较,差异有统计学意义(P<0.05)。组间比较结果显示:术后第3、5、7天,不同肠梗阻并发症患者血浆AGEs水平比较,差异有统计学意义(P<0.05),其中感染患者血浆AGEs水平均高于其他并发症类型者(P<0.05)。组内比较结果显示,不同肠梗阻并发症类型患者术后第3天血浆AGEs水平均高于术后第1天(P<0.05)。结论监测肠梗阻术后患者血浆AGEs水平变化有助于判断患者术后是否出现并发症,并且当患者血浆出现高浓度AGEs时,应当高度怀疑存在局部或全身感染。
Objective To investigate the significance of the plasma level of advanced glycation end products（ AGEs）in the evaluation of patients＇ condition after operations for intestinal obstruction. Methods A total of 376 patients with intestinal obstruction who were admitted into the Department of Gastroenterological Surgery of First Affiliated Hospital of Liaoning Medical University from May 2010 to February 2014 were enrolled. 324 patients without postoperative complications were assigned into the control group,and patients with postoperative complications were assigned into the trial group（ n = 52）,in which 11 patients had infection,16 had intestinal dysfunction,8 had dysglycemia,5 had anastomotic rupture and fistula,8 had acute respiratory distress syndrome（ ARDS） and 4 had mesenteric artery embolization. On day 1,3,5,7 and 14 after operations,3 ml of sterile blood was collected from each patient and the plasma level of AGEs was tested using ELISA method. Results Two groups were significantly different in the plasma level of AGEs at different time points（ P〈0. 05）. The comparison between two groups showed that two groups were not significantly different in the plasma level of AGEs on day 1 and 14（ P〉0. 05） and the trial group was higher than the control group in the plasma level of AGEs on day 3,5 and 7（ P〈0. 05）. The comparison within the trial group showed that the plasma level of AGEs on day 3 was higher than that on day 1（ P〈0. 05）. Patients with different complications were significantly different in the plasma level of AGEs at different time points after operations（ P〈0. 05）. On day 3,5 and 7, patients with different complications were significantly different in the plasma level of AGEs（ P〈0. 05）.Patients with infection were all higher than patients with other complications in the plasma level of AGEs（ P〈0. 05）. For allpatients with complications,the plasma level of AGEs on day 3 was higher than that on day 1（ P〈0. 05）. Conclusion Postoperative monito
出处
《中国全科医学》
CAS
CSCD
北大核心
2015年第11期1280-1283,共4页
Chinese General Practice
关键词
糖基化终产物
高级
肠梗阻术后
术后并发症
Glycation end products
advanced
After operations for intestinal obstruction
postoperative complication
