摘要
目的分析多形性肺癌的外科治疗以及有无淋巴结转移对患者预后的影响。方法 2001年1月至2013年8月进行手术治疗的多形性肺癌患者24例,年龄45～77岁。其中中央型肺癌6例,周围型肺癌18例。术后随访60～112个月。Kaplan—Meier法计算生存率,Logrank法进行生存率的差异性检验。结果 24例术后病理确诊为多形性肺癌,ⅠA期2例,ⅠB期4例,ⅡA期6例,ⅡB期6例,ⅢA期6例。有淋巴结转移12例,其中N1 8例,N24例。均予手术治疗,其中行完全切除20例,行肉眼根治切除（镜检切缘显示阳性）4例。无手术死亡病例。24例患者3、5年生存率分别为41.67%、29.17%,无淋巴结转移患者（12例）3、5年生存率分别为45.00%、35.00%,有淋巴结转移者（12例）3、5年生存率分别为33.33%、25.00%。有无淋巴结转移患者3、5年生存率差异有统计学意义（P=0.023）。结论多形性肺癌预后差,应早期手术。有无淋巴结转移是影响患者预后的重要因素。
Objictive To summarize the surgical treatment and analyze the influence of lymphatic metastasis on outcome in 24 patients with pleomorphic pulmonary carcinoma. Methods Twenty-four patients with pleomorphic pulmonary carcinoma including 6 cases of central lung cancer and 18 cases of peripheral lung cancer treated by operation between January2001 and August 2013 were selected in this study. The patients were 45 to 77 years old. The patients were followed up for60 to 112 months. Kaplan-Meier method was used to calculate the survival rate,and Logrank method was used to conduct the significance testing of survival rate. Results All the 24 patients were confirmed as pleomorphic pulmonary carcinoma by pathology after operation including 2 cases for stage ⅠA,4 cases for stage ⅠB,6 cases for stage ⅡA,6 cases for stageⅡ B,6 cases for stage ⅢA. Lymphatic metastasis was seen in 12 cases including 8 cases for phase N1 and 4 cases for phase N2. All patients received operation therapy including 20 cases of completely removal and 4 cases of radical resection for the naked eye（ presenting positive cancer cells at incisal edge by microscopic examination）. There were no death cases caused by operation. The 3-,5-year survival rates of all patients were 41. 67% and 29. 17%,respectively. The 3-,5-year survival rates were 33. 33% and 25. 00%,respectively for the cases with lymphatic metastasis and 45. 00% and 35. 00%,respectively for the cases without lymphatic metastasis; there were statistical differences in 3-,5-year survival rates between presence and absence of lymphatic metastasis（ P = 0. 023）. Conclusions The prognosis of pleomorphic pulmonary carcinoma is poor,and the operation should be early done. Nodal status is an important factor influencing prognosis.
出处
《中国临床研究》
CAS
2015年第4期429-431,435,共4页
Chinese Journal of Clinical Research
关键词
肺癌
多形性
中央型
周围型
手术治疗
淋巴结转移
预后
Pleomorphie pulmonary carcinoma
Lung cancer, central type, peripheral type
Operation treatment
Lymphatic metastasis
Prognosis
