摘要
目的分析革兰阴性杆菌血流感染病例的临床及病原学特点,为临床诊治提供帮助。方法收集确诊355例革兰阴性杆菌血流感染患者的临床资料及病原学结果,进行回顾性分析研究。结果糖尿病和泌尿系疾病的患者、接受机械通气的患者及有胃肠道感染的患者易发生革兰阴性杆菌血流感染;使用静脉导管、有皮肤黏膜和中枢神经感染的患者易发生非革兰阴性杆菌血流感染。革兰阴性杆菌血流感染患者更易引发脓毒性休克。革兰阴性杆菌血流感染组的降钙素原(PCT)和白细胞介素6(IL-6)水平高于非革兰阴性杆菌血流感染组,差异有统计学意义(P<0.05)。该院引发血流感染的革兰阴性杆菌对碳青霉烯类抗菌药物保持高度敏感。结论分析病原菌的侵入途经、基础疾病、实验室指标并结合细菌耐药情况有助于对革兰阴性杆菌血流感染病例的预测及早期经验性用药。
Objective In order to offer guides for experimental medication,we analyzed the clinical and microbiological characteristics of patients with gram-negative bacteria blood infection in the People＇s Hospital of Chuxiongl.Methods Microbiological and clinical data of 355 patients with gram-negative bacteria blood infection were retrospectively collected and evaluated.Results Compared with other patients,the patients with diabetes and urinary tract disease were more easily attacked by gram-negative bacteria blood infection.The patients using mechanical ventilation and patients with the urinary tract and gastrointestinal tract infection source were more likely attacked by gram-negative bacteria blood infection.The patients with the skin infection source,the catheter infection source,and the central nervous infection source were liable to cause non gram-negative bacteria blood infection.Septic shock was more likely to occur in patients of gram-negative bacteria blood infection.Gram-negative bacteria species in the hospital were still highly susceptible to Carbapenems.Conclusion Analysis of route of pathogen invasion,basic diseases,laboratory indicators and bacterial drug resistance could help forecast for gram-negative bacteria blood infection and guide the early experience administration.
出处
《临床荟萃》
CAS
2015年第4期400-403,共4页
Clinical Focus
关键词
出血性败血症
革兰氏阴性菌
药敏试验
hemorrhagic septicemia
gram-negative bacteria
susceptibility test
