摘要
为考察利培酮微球中结晶型药物对药物释放的影响,采用溶剂挥发法制备了利培酮微球,用扫描电镜观察微球的外观和截面,并建立了X-射线衍射法定量测定微球中结晶型药物含量的方法。结果表明,不同工艺制备的微球其内部药物结晶的形态和数量不同,结晶型药物含量越高体外释药停滞期越长。
Risperidone microspheres were prepared by the emulsion-solvent evaporation method. The scanning electron microscopy was used to observe the surface and cross-section of the microspheres. In order to investigate the effect of crystalline risperidone in microspheres on the drug release from the microspheres, an X-ray powder diffractometric method was developed to quantify the content of crystalline risperidone in the microspheres. Consequently, the different size and quantifi cation of crystalline risperidone in the microspheres prepared by different process were observed. With the content of crystalline risperidone increasing in the microspheres, the latent period of the drug release was prolonged.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2015年第4期369-374,共6页
Chinese Journal of Pharmaceuticals
基金
国家"重大新药创制"科技重大专项(2012ZX09304004)
关键词
利培酮
微球
X-射线衍射
药物结晶
体外释药
risperidone
microsphere
X-ray powder diffractometry
crystalline drug
in vitro drug release
