摘要
目的研究不稳定心绞痛（UA）患者炎性标志物与心率变异性之间的关系。方法自2013年6月至2014年6月在山东中医药大学附属医院心内科住院的UA患者40例,女性26例,男性14例,年龄50~80岁。将研究对象分为hs-CRP〈1.0组mg/L（n=15）,hs-CRP（1.0~3.0）mg/L组（n=16）,hs-CRP〉3.0 mg/L组（n=9）。所有患者进行24 h动态心电图检测获取心率变异性（HRV）,计算时域指标及频域指标。同时检测炎症因子超敏C反应蛋白（hs-CRP）和白介素-6（IL-6）含量。分析hsCRP、IL-6的自然对数与SDNN、RMSSD的关系。结果 hs-CRP（〉3 mg/L）组较hs-CRP（1~3 mg/L）组SDNN和RMSSD均降低,差异有统计学意义（P均〈0.05）。各组间频域指标比较,随hs-CRP的升高,其低频（LF）、高频（HF）、极低频（VLF）和总功率（TP）逐渐降低,但各组间差异无统计学意义（P均〉0.05）。单因素相关分析显示hs-CRP自然对数（Lnhs-CRP）与SDNN之间存在负相关性（r=-0.365,P=0.022）,而Lnhs-CRP与RMSSD之间无明显相关。IL-6自然对数（Ln IL-6）与SDNN呈负相关（r=-0.700,P〈0.001）,与RMSSD呈负相关（r=-0.457,P=0.003）。结论 UA患者HRV的降低与体内炎性标记物hs-CRP、IL-6增加相关。
Objective To study the relationship between inflammatory cytokines and heart rate variability （HRV） in patients with unstable angina pectoris （UAP）.Methods UAP patients （n=40, female 26, male 14 and aged from 50 to 80） were chosen from June 2013 to June 2014, and then divided into [high sensitivity C-reactive protein （hs-CRP）〈1.0 mg/L group,n=15], [hs-CRP=（1.0~3.0） mg/L group,n=16], and （hs-CRP〉3.0mg/L group,n=9）. All patients were given 24h Holter for detecting HRV and calculating time-domain index and frequency-domain index. The levels of hs-CRP and interleukin-6 （IL-6） were detected. The relationships between the natural logarithms of hs-CRP or IL-6 and SDNN or RMSSD were analyzed.Results SDNN and RMSSD decreased inhs- CRP〉3.0mg/L group compared with hs-CRP=（1.0~3.0） mg/L group （allP〈0.05）. The comparison in frequency-domain index showed that LF, HF, VLF and TP decreased gradually as hs-CRP increased but there was no statistical difference among all groups （allP〉0.05）. The single factor correlation analysis showed that the natural logarithms of hs-CRP was negatively correlated to SDNN （r=-0.365,P=0.022）, while not correlated to RMSSD, and the natural logarithms of IL-6 was negatively correlated to SDNN （r=-0.700,P〈0.001） and RMSSD （r=-0.457,P=0.003）.Conclusion The decrease of HRV is correlated to the increases of inflammatory cytokines （hs-CRP and IL-6） in UAP patients.
出处
《中国循证心血管医学杂志》
2015年第2期211-214,224,共5页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
国家自然科学基金项目(81072962)
关键词
不稳定心绞痛
心率变异性
超敏C反应蛋白
白介素6
相关性分析
Unstable angina pectoris
Heart rate variability
High sensitivity C-reactive protein
Correlation analysis
