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粒-巨噬细胞集落刺激因子及其受体拮抗剂mavrilimumab在类风湿关节炎中研究进展 被引量：2

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摘要 RA是一种系统性慢性自身免疫性疾病,以持续侵蚀性的炎症性多关节炎为主要临床表现,除关节外,也可累及肺、心脏、皮肤等其他脏器,如果没有得到合理的治疗,将导致关节毁损和瘫痪,生活质量下降和寿命缩短.粒-巨噬细胞集落刺激因子（granulocyte-macrophage colony stimulating factor,GM-CSF）是一种具有多效性的造血细胞生长因子,在粒细胞系与巨噬细胞系的发育与成熟的各阶段起到调控作用.近年研究表明GM-CSF在炎症反应与自身免疫疾病中有重要作用,GM-CSF参与RA发病,而其受体拮抗剂mavrilimumab能够拮抗GM-CSF信号传导,显著改善关节炎小鼠的症状.为此,本文将综述GM-CSF及其受体拮抗剂mavrilimumab在RA治疗中的研究进展.
作者 盛君 陆进明
机构地区 安徽省皖南医学院附属医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2015年第4期285-288,共4页 Chinese Journal of Rheumatology
关键词 粒-巨噬细胞集落刺激因子 类风湿关节炎 受体拮抗剂 GM-CSF 慢性自身免疫性疾病 造血细胞生长因子 自身免疫疾病 巨噬细胞系
分类号 R593.22 [医药卫生—内科学]
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参考文献30

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中华风湿病学杂志
2015年 第4期

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