摘要
目的:分析中西医结合治疗中晚期结肠癌患者的临床效果及安全性.方法:选取2008-07/2012-06镇海龙赛医院收治的中晚期结肠癌患者142例,均采用F O L F O X4方法化疗,而观察组再给予中药扶正消积汤治疗,治疗后观察治疗效果.结果:观察组治疗总有效率49.3%,显著性高于对照组的29.6%(P<0.05).治疗后对照组C D4+、CD8+及CD4+/C D8+分别为33.9%±5.8%、24.3%±5.2%及1.39±0.34;治疗后观察组CD4+、CD8+及CD4+/CD8+分别为37.5%±5.9%、29.1%±5.7%及1.24±0.31;治疗后两组患者这些指标均有所改善,但观察组改善情况显著性优于对照组(P<0.05).两组间肝功能损害,血小板减少发生率差异无统计学意义(P>0.05),但观察组胃肠道反应,恶心呕吐及脱发发生率显著性低于对照组(P<0.05).结论:中西医结合治疗中晚期结肠癌患者的临床效果满意,可显著提高治疗总有效率,降低治疗不良反应发生率,建议在临床治疗中推广应用.
AIM：To evaluate the clinical efficacy and safety of combined Western medicine and traditional Chinese medicine treatment for patients with advanced colon cancer.METHODS：One hundred and forty-two patients with colon cancer were divided intoeither a control group or a treatment group.Both groups received FOLFOX4 chemotherapy,and the treatment group additionally received traditional Chinese medicine.Clinical efficacy and safety were compared for the two groups.RESULTS：The total response rate in the treatment group was 49.3%,which was significantly higher than that in the control group（P 〈0.05）.The proportions of CD4^＋,CD8^＋ lymphocytes and CD4^＋/CD8^＋ ratio in the control group after treatment were 33.9% ± 5.8%,24.3% ± 5.2% and 1.39 ± 0.34,respectively; the corresponding values for the treatment group were 37.5% ± 5.9%,29.1% ± 5.7% and 1.24 ± 0.31.These parameters were significantly improved in both groups after treatment,and the improvement was more significant in the treatment group（P 〈0.05）.The incidence rates of hepatic dysfunction and thrombopenia between the two groups had no significant difference（P 〉0.05）.The incidence rates of gastrointestinal reaction,nausea,vomiting and hair loss in the treatment group were significantly lower than those in the control group（P 〈0.05）.CONCLUSION：Combined Western medicine and traditional Chinese medicine treatment for patients with advanced colon cancer is effective and safe.
出处
《世界华人消化杂志》
CAS
2015年第10期1660-1663,共4页
World Chinese Journal of Digestology
关键词
结肠癌
化疗
中医
临床效果
Colon cancer
Chemotherapy
Traditional Chinese medicine
Clinical efficacy
