摘要
以3,4-二甲氧基苯甲酸为原料,经硝化、脱甲基、还原、环合、乙酰化、氯化、缩合、水解等反应,最后经过一步与N-(3-氯丙基)吗啉缩合得到抗肿瘤药吉非替尼。
Gefitinib was synthesized from 3,4-dimethoxy benzoic acid by nitrification, demethylation, reduction, cyclization, acetylation, chlorination,condensation, hydrolysis, and the final condensation with N-(3- chloropropyl) morpholine.
出处
《药学与临床研究》
2015年第2期147-149,共3页
Pharmaceutical and Clinical Research
