摘要
目的:观察医用臭氧联合恩替卡韦(ETV)治疗高病毒载量(HBV DNA≥107拷贝/ml)慢性乙型病毒性肝炎的临床疗效。方法:选择2010年2月至2014年5月96例HBe Ag阳性高病毒载量慢性乙型病毒性肝炎成年患者,在知情同意基础上按照随机数字表法随机分为治疗组与对照组各48例,分别给予医用臭氧/ETV联合治疗和单纯ETV治疗,疗程12周时观察2组HBe Ag转换率、病毒学应答率等指标。结果:2组治疗前肝功能各项指标比较无显著性差异(P>0.05),治疗后各项指标均较治疗前有显著改善(P<0.01),同期比较治疗组较对照组ALT、AST及TBil改善明显(P<0.01)。治疗组联合应答率(CR)、病毒学应答率(VR)、生化学应答率(BR))及HBe Ag血清转换率均明显高于对照组(P<0.01)。结论:医用臭氧联合恩替卡韦治疗高病毒载量慢性乙型病毒性肝炎可提高HBe Ag血清转换率,快速降低病毒载量,改善肝功能,缩短病程,值得推广应用。
Objective： To investigate the medical ozone combined with enteeavir （ETV） in treatment of high viral toad （HBV DNA〉107 copies/ml） clinical effects of chronic viral hepatitis B. Methods： From February 2010 to February 2012,96 cases of chronic hepatitis B in HBeAg-positive patients with high viral load in adult patients on the basis of informed consent in accordance with the random random number table divided into treatment group and control group, 48 cases were given medical ozone / ETV ETV treatment alone and combination therapy, observed two groups HBeAg conversion rate, and other indicators of virologic response rates when treatment for 12 weeks.Resuls： The results showed no significant difference （P〉0.05） 2 groups of the indicators of liver function before treatment, before all parameters were significantly improved treatment （P〈0.01）, compared with same period the treatment group compared with the control group after treatment ALT, AST and TBil improved significantly （P〈0.01）, Combined response rate of the treatment group, virologic response rates, biochemical response rate and HBeAg seroconversion rate was significantly higher （P〈0.01）.Results： The results showed no significant difference （P〉0.05） 2 groups of the indicators of liver function before treatment, before all parameters were significantly improved treatment （P〈0.01）, compared with same period the treatment group compared with the control group after treatment ALT, AST and TBil improved significantly （P〈0.01）. Combined response rate of the treatment group, virologic response rates, biochemical response rate and HBeAg seroconversion rate was significantly higher （P〈0.01 ）.
出处
《中国医学装备》
2014年第B08期40-40,共1页
China Medical Equipment
