摘要
以呼和浩特市生活饮用水为研究对象,从危害识别、危害描述、暴露评估、风险描述4个方面对水中亚硝酸盐的危害进行风险评价,确定其风险商(QH)为40%。QH<1,说明通过饮用水途径摄入亚硝酸盐对人体健康造成风险的可能性不大。同时,以纯昆明种小鼠为试验动物,开展了亚硝酸盐亚急性毒理学试验,测定血清生化指标。结果表明:基于膳食暴露水平给药的试验组,乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、尿素(UREA)与对照组有显著性差异,肝肾功能受到一定的影响。忽略从试验动物向人群外推时的不确定性,膳食暴露水平的亚硝酸盐对人体的肝肾功能也可能产生不良的影响。
Taking drinking water of Hohhot City as the research object, a risk evaluation on the hazard factor of nitrite in water was made from four aspects such as hazard identification, hazard description, exposure assessment and risk description. The evaluation results show that the risk quotient （ QH） of nitrite in water is 40%, which indicates that the possibility that human＇ s intaking nitrite by drinking water causes risk to human health is little. In the meantime, taking pure Kunming mice as experimental animals, a nitrite sub acute toxicological test was made to determine the serum biochemical index. The results show that there are significant differences in the lactate dehydrogenase （LDH）, aspartate amino transferase （AST） , alanine aminotransferase （ALT） and urea between the experimental group, which is given nitrite according to the level of dietary exposure, and the control group. The function of liver and kidney of mice in the experimental group has been affected. Ignoring the uncertainty from the experimental animal to human, nitrite in a level of the dietary exposure maybe have bad influence to the function of human＇ s liver and kidney.
出处
《水资源保护》
CAS
CSCD
2015年第2期55-58,共4页
Water Resources Protection
基金
内蒙古自治区农牧业科学院青年创新基金(2012QNJJN05)
