摘要
弥漫大B细胞淋巴瘤（DLBCL）为常见的侵袭性淋巴瘤,其中活化B细胞样（ABC）亚型DLBCL患者复发率高、生存率低,预后差.核因子（NF）-κB信号通路持续过度活化,是区分ABC亚型DLBCL与其他亚型DLBCL的显著特征之一,亦为导致ABC亚型DLBCL疾病发生的关键信号通路.近年,多项研究结果证实CARMA1通过调控NF-κB信号通路,进而在ABC亚型DLBCL疾病发生中发挥重要作用.笔者拟就CARMA1功能、基因点突变及翻译后修饰等方面对ABC亚型DLBCL疾病发生的影响进行综述.
Diffuse large B cell lymphoma （DLBCL） is a common and aggressive lymphoma.Activated B cell-like （ABC） subtype of DLBCL patients are characterized by high recurrence rate,low survival rate and poor prognosis.Continued excessive activation of Nuclear factor （NF）-κB signaling pathway is the most significant feature of ABC subtype of DLBCL which differentiate it from other subtypes of DLBCL,and it is also one of the key signaling pathways which lead to ABC subtype of DLBCL.In recent years,many research results confirmed that CARMA1 plays an important role in ABC subtype of DLBCL occurrence through the regulation of NF-κB signaling pathway.The article reviews literatures on CARMA1 function,gene mutation and post translation modification impact on ABC subtype of DLBCL.
出处
《国际输血及血液学杂志》
CAS
2015年第2期157-161,共5页
International Journal of Blood Transfusion and Hematology
基金
国家自然科学基金资助项目（81400167）
江苏省自然科学基金青年基金资助项目（BK20140227）
