摘要
目的探讨急性冠脉综合征(acute coronary syndrome,ACS)合并糖耐量受损(impaired glucose tolerance,IGT)患者临床特点、近期预后及其相关危险因素.方法对冠状动脉造影明确ACS诊断且既往无糖尿病患者,且经检测符合入选条件并能按时随访的分为血糖正常(normal glucose regulation,NGR)、IGT、空腹血糖受损(impaired fasting glucose,IFG)3组,搜集一般资料,进行生化及糖耐量试验,行冠状动脉造影、随访临床事件.结果 (1)IGT组双支、三支血管病变数、右冠状动脉病变率、Gensini积分、血管病变程度重较明显,差异有统计学意义(P<0.05);(2)住院期间严重出血、死亡及联合终点事件在IGT组明显升高,出院后1月内再发心肌梗死、心力衰竭、卒中、严重出血、死亡及联合终点事件在IGT组明显升高,差异有统计学意义(P<0.05);结论 ACS合并IGT患者冠脉病变重、近期预后差,应引起高度重视.
Objective To study the clinical features, early prognosis and relative risk factors of patients with acute coronary syndrome （ACS） and impaired glucose tolerance （IGT） Methods Patients with a definite ACS diagnosis diagnosed by coronary arteriongraphy were checked in accordance with the selected conditions as well as timely follow-up, then were divided into three groups： normal glucose regulation group （NGR） , IGT group and impaired fasting glucose group （IFG） . The general information were collected, biochemical parameters were detected, glucose tolerance test, coronary arteriongraphy and follow-up clinical incidents were performed. Results 1） More cases of double or three branch lesion, right coronary artery disease, unfavorable Gensini scores and serious vasculopathy occurred in IGT group, and there were significant differences compared with other groups （P 〈 0.05） . 2） In IGT group, not only the rates of severe bleeding, death and combined endpoint events in hospitalization but also the recurrence of myocardial infarction, cardiac failure, stroke, serious bleeding, death and combined endpoint events in 1 month after discharge from the hospital were significantly increased. The differences among the three groups had statistical significance （P 〈 0.05） . Conclusion Special attention should be paid to patients with ACS and IGT due to their serious coronary artery lesions and unfavorable early prognosis.
出处
《昆明医科大学学报》
CAS
2015年第4期87-92,共6页
Journal of Kunming Medical University
关键词
急性冠脉综合征
糖耐量受损
临床特点
早期预后
Acute coronary syndrome
Impaired glucose tolerance
Clinical features
Early prognosis
