摘要
目的分析血液灌流(HP)治疗急性有机磷农药中毒的治疗效果及并发症,寻求治疗急性重度有机磷农药中毒的科学方法。方法收集2009年1月至2013年12月于广州番禺区何贤纪念医院重症监护病房的急性有机磷农药中毒患者87例的临床资料,根据患者意愿分为常规治疗联合HP治疗组(治疗组,n=51)和常规治疗组(对照组,n=36),统计分析两组病人的治疗效果和并发症。结果治疗组阿托品总剂量、氯磷定总剂量、胆碱酯酶恢复时间、住院时间、恢复清醒时间、使用呼吸机时间均较对照组减少或缩短,差异有统计学意义(P<0.05或P<0.01),且治疗组治愈率明显高于对照组(P<0.01);治疗组中间综合征、肺部感染、呼吸衰竭、血压升高、肺水肿、深度昏迷、大小便失禁等并发症的发生率明显低于对照组,差异有统计学意义(P<0.01),消化道出血的发生率差异无统计学意义(P>0.05)。结论使用血液灌流抢救急性有机磷中毒患者能够取得良好的治疗效果并减少并发症的发生,值得推广应用。
Objective To study the therapeutic effect and complications of hemoperfusion in the treatment of acute organophosphorus pesticide poisoning. Methods The clinical data of 87 patients with acute organophosphorus pesticide poisoning were collected from 2009 January-2013 December. 51 cases were willing to accept conventional therapy combined with hemoperfusionas experimental group; 36 cases received conventional treatment as control group.The outcomes of 2 groups of patients were statistically analyzed. Results There were significant differences in the total doses of atropine,total doses of pralidoxime chloride, cholinesterase recovery time, hospitalization time,and cure rate（P〈 0.01）. The time of consciousness recovery and the time of using respirator were also significantly different（P〈0.05）. The occurrence rates of intermediate syndrome, pulmonary infection, respiratory failure, pulmonary edema, elevated blood pressure, deep coma, incontinence and other complications of the two groups were significant different（P 〈0.01）. The incidence of gastrointestinal bleeding of two groups were not significantly different（P 〉0.05）. Conclusion The use of hemoperfusionin the treatment of acute organophosphorus pesticide poisoning patients can achieve good therapeutic effect and reduce complications, and is worthy of popularization and application.
出处
《热带医学杂志》
CAS
2015年第3期359-361,共3页
Journal of Tropical Medicine
关键词
血液灌流
有机磷农药中毒
疗效分析
hemoperfusion
organophosphate poisoning
clinical analysis
