摘要
目的探讨多西他赛联合奈达铂同步调强适形放疗对局部晚期鼻咽癌患者的临床疗效。方法选择78例局部晚期鼻咽癌患者,按照随机数表法分为观察组和对照组,每组39例。对所有患者均实施根治性6 MV X线外照射放疗,观察组患者在放疗的基础上行同步化疗。对两组患者的生存状况、不良反应和临床疗效进行比较。结果观察组患者的治疗有效率（89.8%）明显高于对照组（69.2%）,差异有统计学意义（P〈0.05）。观察组患者治疗后2年局部区域无进展生存率为100.0%,2年无远处转移生存率为92.3%,总生存率为92.3%,均显著优于对照组,差异有统计学意义（P〈0.05）。观察组患者的Ⅲ-Ⅳ度白细胞减少、中性粒细胞减少发生率分别为48.7%和33.3%,显著高于对照组,差异有统计学意义（P〈0.05）。两组患者血小板减少和贫血发生率的差异无统计学意义（P〉0.05）。观察组患者的Ⅲ-Ⅳ度恶心、食欲减退和呕吐发生率均低于对照组,差异有统计学意义（P〈0.05）。在腹胀、肝功能损伤以及口腔黏膜反应等方面,组间差异无统计学意义（P〉0.05）。结论多西他赛联合奈达铂同步调强适形放疗不但使局部晚期鼻咽癌患者的治疗增益,而且有利于提高患者的生存率,改善生存质量,增加无瘤生存率,减少不良反应的发生,其临床疗效较好,值得临床推广。
Objective To investigate clinical curative effect of docetaxel combined with nedaplatin concurrent intensity modulated conformal radiotherapy in the treatment of patients with locally advanced nasopharyngeal carcinoma. Methods A total of 78 cases of patients with locally advanced nasopharyngeal carcinoma were selected and divided into observation group and control group,and each group had 39 cases. All patients were implemented radical 6 MV X line external beam radiotherapy,and observation group patients also received chemotherapy. Living conditions,adverse reactions,clinical effects of two groups were compared. Results The response rate of observation group（ 89. 8%） was significantly higher than that in control group（ 69. 2%）,with statistically significant（ P〈0. 05）. In observation group,2-yr local progression-free survival rate was 100. 0%,2-yr distant metastasis-free survival rate was 92. 3%,and overall survival rate was 92. 3%,significantly better than that of the control group,with statistically significant（ P〈0. 05）. Incidence rates of Ⅲ - Ⅳ degree leukopenia and neutropenia in observation group were48. 7%,33. 3%,respectively,significantly higher than that in control group（ P〈0. 05）. Two groups of patients with thrombocytopenia and anemia was no significant difference（ P〉0. 05）. Incidence rates ofⅢ - Ⅳ degree nausea /loss of appetite and vomiting were lower than that in control group,with statistical significance（ P〈0. 05）. In abdominal distention,liver function damage and oral mucosa reaction,there was no significant difference between two groups（ P〉0. 05）. Conclusions The docetaxel combined with nedaplatin synchronous intensity modulated conformal radiotherapy for locally advanced nasopharyngeal carcinoma patients not only have therapeutic gain,but also help to improve the survival rate of patients,improve quality of life,increase disease-free survival,reduce adverse reactions occurrence,increase clinical efficacy,and is worthy of widely used.
出处
《中国肿瘤临床与康复》
2015年第4期434-437,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
鼻咽肿瘤
多西他赛
奈达铂
同步调强适形放疗
治疗结果
Nasopharyngeal neoplasms
Docetaxel
Nedaplatin
Synchronous intensity mod-ulated conformal radiotherapy
Treatment outcome
