摘要
目的:探讨中西医结合治疗难治性血小板减少症(r ITP)的临床效果。方法:将35例r ITP患者,随机分成两组,分别采用单纯西药(强的松、长春地辛)和中西医结合(强的松、益气养血活血方)进行治疗,6个月后观察治疗效果,对比分析患者外周血和骨髓相关指标的变化。结果:中西医结合治疗r ITP的总有效率和完全反应率均明显高于单纯西医治疗(P<0.05)。患者血小板的指标中,治疗后中西医结合组血小板计数(PLT),血小板压积(PCT)升高水平均高于单纯西医治疗组(P<0.01),而血小板平均体积(MPV),血小板体积分布宽度(PDW)下降水平均低于单纯西医治疗组(P<0.01)。中西医结合治疗组患者血小板抗体相关免疫球蛋白G(PAIg G)升高水平明显大于单纯西医治疗组(P<0.01)。中西医结合治疗组患者骨髓中巨核细胞升高水平明显大于单纯西医治疗组(P<0.05),颗粒巨核细胞与裸核巨核细胞治疗后较治疗前明显减少。结论:中西医结合(强的松、益气养血活血方)对r ITP具有较好的疗效。
Objective： The aim of this study was to compare the effect between Western medicine treatment combined with treatment of traditional Chinese medicine （Yiqi Yangxue Huoxue Fang） and western medicine alone in patients with refractory idiopathic thrombocytopenic purpura （rITP）. Method： In this study, 35 rITP patients were divided into two groups which were treated with Western medicine combined with traditional Chinese medicine and western medicine alone, respectively. The curative effects were evaluated after 6 months. l-esuit： Both total effective rate and complete reaction rate of rITP patients treated with combination of traditional Chinese medicine and western medicine were much higher than those treated with Western medicine alone. After treatment, platelet count （PLT） and plateletcrit （PCT） were much higher and mean platelet volume （MPV） and platelet distribution width （PDW） were much lower （P 〈0.01） in the combination treatment group than those in western medicine alone treatment group. Platelet associated IgG （PAIgG） increased much higher in combination treatment group than those in western medicine alone treatment group, and so were the platelet-producing megakaryocytes in bone marrow smear. Conclusion： The combination treatment of traditional Chinese medicine （Yiqi Yangxue Huoxue Fang） with western medicine had a good curative effect in rITP patients.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第8期173-176,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81273987)
山东省中医药科技发展计划项目(2013-246)
潍坊市中医药科学技术研究项目(2013-028)
关键词
难治性血小板减少症
血小板相关抗体
中西医结合治疗
refractory idiopathic thrombocytopenic purpura
platelet associated immunoglobulin
combined treatment of traditional Chinese medicine and western medicine
