摘要
目的探讨乌司他丁治疗危重症血流感染患者全身炎性反应的临床效果,为临床治疗提供参考依据。方法选取2010年3月-2013年12月危重症患者血流感染所致全身炎性反应的74例,随机分为两组,对照组35例实施常规治疗,观察组39例在对照组基础上加用乌司他丁静脉滴注;记录其观察体温、呼吸频率、心率、白细胞计数、血肌酐、血乳酸、C-反应蛋白、炎症因子水平及记录有创机械通气、ICU住院时间以及病死率等指标,数据采用SPSS13.0进行统计分析。结果对照组患者有创通气时间、ICU住院时间、病死率分别为(16.42±1.28)d、(27.72±3.17)d和31.43%,观察组分别为(7.33±0.52)d、(15.23±1.44)d和5.13%,观察组患者治疗时间和病死率均明显少于对照组,两组比较差异有统计学意义(P<0.05)。结论对血流感染所致全身炎症反应的危重症患者实施乌司他丁治疗,可以显著改善患者生命体征、有效保护患者的肝肾功能、缩短治疗时间、改善预后,而且给药方便,可以作为一种常规的治疗手段进行临床推广。
OBJECTIVE To investigate the clinical effect of ulinastatin in the treatment of systemic inflammatory response in patients with critical bloodstream infections so as to provide reference for clinical treatments.METHODS Totally 74 cases of critical patients with systemic inflammatory response caused by bloodstream infections were selected from Mar.2010 to Dec.2013 and they were randomly divided into two groups.Conventional treatment was adopted in the control group with 35 patients and another 39 patients were given ulinastatin intravenously on the basis of the control group.Indicators like temperature,respiratory rate,heart rate,leukocyte numbers,serum creatinine,blood lactic acid,C-reactive protein and inflammatory cytokines were observed and recorded.Other indicators like invasive mechanical ventilation,hospital stays in ICU and fatality rate were recorded too.SPSS 13.0software was adopted for statistical analysis.RESULTS The invasive ventilation time,ICU length of stay and mortality rate in control group were respectively（16.42±1.28）d,（27.72±3.17）d and 31.43%.In the observation group,they were（7.33±0.52）d,（15.23±1.44）d and 5.13%.The curative time and mortality rate in the observation group were significantly less than the control group（P〈0.05）.CONCLUSIONUlinastatin treatment for critical patients with systemic inflammatory response caused by bloodstream infections can significantly improve the patient＇s vital signs,effectively protect the patient＇s liver and kidney function,shorten treatment time and improve patients prognosis,and ease administration,hence it can be used as a routine means of treatment to promote in clinic.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第7期1541-1543,共3页
Chinese Journal of Nosocomiology
基金
浙江省卫生厅科技基金资助项目(ZW-2012B-041)
关键词
乌司他丁
危重患者
血流感染
全身炎症反应
Ulinastatin
Critically ill patients
Bloodstream infections
Systemic inflammatory response
