摘要
颅内动脉粥样硬化性疾病(intracranial atherosclerotic disease,ICAD)是国人缺血性卒中主要原因,防治难点在于卒中高危人群筛查及有效治疗方法的选择(药物治疗/介入治疗)。3.0 T HR MRI具有在体、无创、无电离辐射等优势,能够从管壁结构及斑块特性的视角筛选大脑中动脉(middle cerebral artery,MCA)粥样硬化狭窄的卒中高危因素,观察疾病进程和临床疗效,具有潜在的预判介入手术获益人群的优势,临床应用前景广阔。目前HR MRI在MCA狭窄患者评估中的应用研究主要集中在方法学可行性、诊断与鉴别诊断、病因学等3方面,缺乏临床疗效评估及预后因素分析(尤其是术后再狭窄)相关实践,值得深入探讨。
Intracranial atherosclerotic disease（ICAD） of a major intracranial artery, including middle cerebral artery（MCA）,basilar artery, is the most common causes of stroke and is associated with a high risk of recurrent stroke in China. The difficulty to treatment these high-risk disease is to identify high-risk stroke subgroups and to develop more effective treatments（aggressive medical therapy/endovascular therapy）. With the benefits, including non- invasive, in vivo, and no- ionizing radiation, 3.0 Tesla high-resolution magnetic resonance imaging（HR MRI） could be used to stratify high-risk patients, monitor progression of disease, and evaluate clinical efficacy, based on MCA wall structure and plaque characteristic. HR MRI has the latency of predicting high- risk patients benefit from endovascular therapy, having a broad application prospect during psotSAMMPRIS era. The current research on MCA stenosis using HR MRI focuses on methodology, diagnosis and differential diagnosis, etiology, and lacks of clinical efficiency evaluation and prognostic analysis of ICAD treatment, especially lacks the research on in-stent restenosis, which needs further investigation.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2015年第1期154-158,F0003,共6页
Journal of Southern Medical University
基金
国家自然科学基金(31370810)
上海市市级医院新兴前沿技术联合攻关项目(SHDC12012103)
上海市卫计委青年基金(20144Y0201)~~
关键词
颅内动脉狭窄
动脉粥样硬化
高分辨MR管壁成像
大脑中动脉
斑块
血管壁
intracranial arterial stenosis
atherosclerosis
high-resolution magnetic resonance imaging
middle cerebral artery
plaque
vessel wall
