摘要
目的探讨小动脉闭塞性脑卒中患者出现轻度认知功能障碍的危险因素。方法采用回顾性方法选取1356例TOAST分型为小动脉闭塞性脑卒中患者,根据认知功能筛查结果分为认知功能正常组1279例和轻度认知功能障碍组(MCI组)77例。收集并分析2组患者一般资料、病史、神经心理量表评估和血液学指标。结果 MCI组较认知功能正常组高血压病史(84.42%vs 67.08%)、久坐生活方式(22.08%vs 11.81%)比例高,差异有统计学意义(P=0.002,P=0.008),2组文化程度比较差异有统计学意义(P=0.035)。2组年龄、TG、TC、HDL-C、LDL-C、FPG等比较,差异无统计学意义(P>0.05)。logistic回归分析显示,有高血压病史的患者发生MCI是无高血压病史患者的2.589倍(P=0.003),有久坐生活方式的患者发生MCI的概率是无久坐生活方式患者的2.161倍(P=0.008)。结论高血压和久坐生活方式与SAO患者发生MCI具有较强的相关性,是其独立的危险因素。
Objective To study the risk factors for mild cognitive impairment（MCI）in patients with small artery occlusion（SAO）.Methods A total of 1356 SAO patients were divided into normal cognition group（n=1279）and MCI group（n=77）.Their general clinical data,medical histories,neuropsychological scale score and biochemical indexes were analyzed.Results The incidence of hypertension and the rate of patients with sedentary lifestyle were higher in MCI group than in normal cognition group（84.42%vs 67.08%,P=0.002;22.08%vs 11.81%,P=0.008）.The education level was significantly different in the 2groups（P=0.035）.No significant difference was found in age and serum levels of TG,TC,HDL-C,LDL-C,FPG between the 2groups（P〉0.05）.Logistic regression analysis showed that the incidence of MCI was 2.589-fold higher in hypertensive patients than in non-hypertensive patients（P=0.003）and was 2.161-fold higher in patients with sedentary lifestyle than in those without sedentary lifestyle（P=0.008）.Conclusion Hypertension and sedentary lifestyle are closely related with MCI in SAO patients and are thus the independent risk factors for MCI.
出处
《中华老年心脑血管病杂志》
CAS
2015年第4期393-395,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
小动脉硬化
卒中
认知障碍
高血压
危险因素
arteriolosclerosis
stroke
cognition disorders
hypertension
risk factors
