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老年患者双联抗血小板治疗上消化道出血的危险因素 被引量:11

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摘要 目的探讨双联抗血小板长期治疗老年冠心病患者的安全性及上消化道出血的发生情况及可能的预防措施。方法符合入组标准并最终完成随诊的患者758例,从开始双联抗血小板治疗入组,收集临床资料包括既往病史、入组时的临床用药情况、生化指标及临床转归,观察终点包括发生消化道出血、死亡、停止应用双联抗血小板药物,最长随诊至入组后6个月。结果 48例发生消化道出血,同时应用PPI、H2RA、复方谷氨酰胺颗粒+PPI、复方谷氨酰胺颗粒+H2RA及单纯应用双联抗血小板药物(作为对照组)分别为108、240、70、102、208例,各组间年龄及阿司匹林、硫酸氢氯吡格雷的用法用量均相同,结果发现5组消化道出血分别为4、12、1、3、28例。结论联合应用复方谷氨酰胺颗粒类胃黏膜保护剂与PPI可最大限度地减少消化道出血的发生率。
作者 王青山
出处 《中国老年学杂志》 CAS CSCD 北大核心 2014年第22期6352-6354,共3页 Chinese Journal of Gerontology
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