摘要
以脱镁叶绿酸-a甲酯1为起始原料,利用其的五元外接环的多官能团活性反应区域,分别进行了羟醛缩合反应和还原反应,合成出具有差向异构特征的叶绿素类二氢卟吩衍生物2和3.同时,提出了相应的化学反应机理,并对差向异构体的立体结构进行讨论和表征,解释和总结了脱镁叶绿酸-a甲酯中E-环化学反应的立体选择性.
Methyl pheophorbide-a 1 is used as starting material. The Aldol reaction and reduction are performed,respectively,by using multi-functional active region on the five-membered exocyclic ring to synthesize chlorophyllous chlorins 2 and 3 with stereo-isomeric feature. The corresponding reaction mechanisms are proposed,and the stereo-structures of epimers are discussed and characterized. The stereoselectivity of chemical reactions on the Ering of methyl pheophorbide-a is explained and summarized.
出处
《烟台大学学报（自然科学与工程版）》
CAS
2015年第2期84-89,共6页
Journal of Yantai University(Natural Science and Engineering Edition)
基金
国家自然科学基金资助项目(21272048)
国家科技部中匈政府间合作项目(2013年)
