摘要
MicroRNA（miRNA）是一类内源性的长度约20~24个核苷酸的非编码单链的RNA分子,在细胞发育、增殖、凋亡、分化等方面发挥着重要作用。其中,microRNA-143（miR-143）是一种肿瘤抑制性miRNA,它在多种肿瘤中呈低表达,被视为肿瘤抑制因子,miR-143在其他方面的研究也逐渐增多,因此本文对miR-143在肿瘤、心血管、2型糖尿病并发症以及细胞分化等方面的研究情况做一综述。
MicroRNA （ miRNA） is derived length of about 20-24 nu-cleotides in non-coding single-stranded RNA molecules within a class , in terms of cell growth, proliferation, apoptosis, differentiation plays an important role.Wherein the microRNA -143 is a tumor inhibitory miRNA, which showed low expression in a variety of tumors , is regarded as tumor suppressor.With further research , the study of miR -143 in other areas is gradually increasing , so this aspect of miR -143 in cancer , cardiovascular , type 2 diabetes and other complications , and cell differentiation studies the case reviewed.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第7期573-576,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81102434)
