摘要
目的:加强对新生儿红斑狼疮(NLE)的认识,提高临床诊断的准确率。方法:回顾性分析我科2012年1月—2013年12月8例NLE的临床特点和诊治方法,并复习相关文献。结果:患儿皮损类似亚急性皮肤红斑狼疮(SCLE),局限或全身分布,以面部最为明显,也可累及四肢、外阴及足跖等。患儿及其母亲抗核抗体(ANA)、抗干燥综合征抗原A(SSA)及抗干燥综合征抗原B(SSB)Ig G抗体均阳性,其中3例患儿有轻至中度贫血,1例患儿伴右束支传导阻滞。结论:NLE以皮肤鳞屑性红斑为主要表现,该病的皮损具有自限性,整体预后良好,但仍需长期随访观察。
Objective： To improve the knowledge of neonatal lupus erythematosus（NLE） and thereby improve the accurate diagnosis of the disease. Methods： The clinical features and diagnostic methods of 8 cases of NLE were retrospectively analyzed from January 2012 to December 2013, and the related literatures were also reviewed. Results： The distribution of skin lesions were localized or disseminated, and resembled those of subacute cutaneous lupus erythematosus. The face was almost always affected, the limbs, vulva and soles were affected as well. ANA, anti SSA Ig G and anti SSB Ig G antibodies were positive in the sera of the eight infants and their mothers. Three cases had mild to moderate anemia, one case had right bundle branch block by electrocardiogram. Conclusion： The most common clinical manifestations of NLE is squamous erythema of the skin. The cutaneous lesion is self-limiting with good prognosis, but the long-term prognosis for NLE has to be followed up.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2015年第4期201-203,共3页
Journal of Clinical Dermatology
关键词
红斑狼疮
新生儿
临床表现
文献复习
neonatal lupus erythematosus
clinical features
literature review
