摘要
目的:测试静态IMRT治疗左乳腺癌5种不同主野分布的剂量情况,以期找到较好的主野分布方式。方法:随机选取在云南省肿瘤医院接受术后放射治疗的0-ⅡA期左乳腺癌病人15例,为每例患者设计5个IMRT计划,每个计划的主野数分别为2、3、4、5、8,命名为2-field IMRT、3-field IMRT、4-field IMRT、5-field IMRT、8-field IMRT。在相同的约束条件和寻解路径下,比较5种主野分布下PTV的CI和HI,危及器官的Dmax和Vx(V5,V10,V20,V30……)。结果:从PTV的CI和HI来考察,8-field IMRT计划的CI和HI最好,2-field IMRT和3-field IMRT较差,且容易在乳腺内侧和腋下形成些高剂量点(热点);但8-field IMRT心脏的V10和同侧肺的V5远远超过了规定值。4-field IMRT和5-field IMRT计划能获得与8-field IMRT相近的PTV的CI和HI值,也能很好地保护危及器官。结论 :4-field IMRT和5-field IMRT能满足临床的需要。
Objective To study the dose of five kinds of field-distribution stastic IMRT for left breast cancer, and to find a better field-distribution in IMRT. Methods Randomly select 15 0- II A stage left-breast- cancer patients treated with radiotherapy in Yunnan tumor hospital. Five physical plans were designed for every patient, and the number of field in plans were as follows： 2, 3, 4, 5, 8. Plans were respectively named： 2-field IMRT, 3-field IMRT, 4-field IMRT, 5-field IMRT, 8-field IMRT. Under the same constraint condition, compare results of five kinds of field-distribution. Compared parameters include CI and HI of PTV, Dmax and Vx（Vs, V1o, V20, V30 ） of organs at risk. Results When considering CI and HI of PTV, the best plan is 8-field ｜MRT, and 2-field IMRT and 3-field IMRT are worse, and there are ＂hot point＂ at mammary inner edge and armpit in 2-field IMRT and 3-field IMRT; But V10 of heart and V5 of ipsilateral lung in 8-field IMRT are over the rated value. CI and HI of PTV in 4-field IMRT and 5-field IMRT are similar to those in 8-field IMRT, which can effectively protect organs at risk. Conclusion 4-field IMRT and 5-field IMRT are able to reach clinical need.
出处
《中国医学物理学杂志》
CSCD
2015年第2期210-213,共4页
Chinese Journal of Medical Physics
基金
国家自然科学基金(81101693)
关键词
乳腺癌
主野分布
IMRT
剂量
breast cancer
field-distribution
intensity modulated radiotherapy
dose
