摘要
危重症患者抗菌药的代谢动力学发生改变,肾脏替代治疗也影响药物清除率。应根据药代动力学参数、残余肾清除率、肾脏替代治疗的清除率、药动学目标制定危重症患者个体化的抗菌药剂量。
ABSTRACT The Pharmacokinetics of Critically ill patients would change greatly, renal replacement therapy as well as increase the drugs clearance. To optimize antibiotic therapy, individualization of antibiotic dosing is important. So the Pharmacokinetics, residual renal function, CRRT clearance, Pharmacokineties target should all be considered.
出处
《肾脏病与透析肾移植杂志》
CSCD
北大核心
2015年第1期75-79,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
危重症
肾脏替代治疗
抗菌药
药代动力学
critically ill renal replacement therapy antibacterial agents pharmacokinetics
