摘要
胰岛素样生长因子-1（insulin-like growth factor 1，IGF-1）及其受体（IGF-1R）与肿瘤的关系是近年研究的热点。资料表明由IGF-1R介导IGF-1的活性，促进组织细胞的增殖、分化、抑凋亡以及肿瘤的发生、发展。而肿瘤细胞的增殖、浸润、转移、凋亡及耐药等具体的生物学行为则由IGF-1R通路调节相关因子作用来实现，如MMPs、Bcl-2家族、整合素、血管内皮生长因子等。本文就近年有关IGF-1和IGF-1R通路中涉及到的相关因子等研究进展作一综述。
The relationship between insulin-like growth factor 1 and its receptor with the tumor is a research hotspot in recent years. Data show that the activity of the IGF-1 mediated by IGF-1R,which can promote cell proliferation, differentiation, apoptosis suppression and tumor occurrence and development. And the specific biological behavior of tumor including cell proliferation, invasion, metastasis and apoptosis, and resistance is the manifestation of related factors such as MMPs, Bcl-2 family, integrin, vascular endothelial growth factor, etc. This paper introduced the research progresses on the recent relevant IGF-1 and some related factors involved in IGF-1R signaling pathways.
出处
《中国伤残医学》
2015年第8期200-202,共3页
Chinese Journal of Trauma and Disability Medicine
