摘要
In facing the mounting clinical challenge and suboptimal techniques of craniofacial bone defects resulting from various conditions, such as congenital malformations, osteomyelitis, trauma and tumor resection, the ongoing research of regenerative medicine using stem cells and concurrent advancement in biotechnology have shifted the focus from surgical reconstruction to a novel stem cell-based tissue engineering strategy for customized and functional craniofacial bone regeneration. Given the unique ontogenetical and cell biological properties of perinatal stem cells, emerging evidence has suggested these extraembryonic tissue-derived stem cells to be a promising cell source for extensive use in regenerative medicine and tissue engineering. In this review, we summarize the current achievements and obstacles in stem cell-based craniofacial bone regeneration and subsequently we address the characteristics of various types of perinatal stem cells and their novel application in tissue engineering of craniofacial bone. We propose the promising feasibility and scope of perinatal stem cell-based craniofacial bone tissue engineering for future clinical application.
In facing the mounting clinical challenge and suboptimaltechniques of craniofacial bone defects resulting fromvarious conditions, such as congenital malformations,osteomyelitis, trauma and tumor resection, the ongoingresearch of regenerative medicine using stem cells andconcurrent advancement in biotechnology have shiftedthe focus from surgical reconstruction to a novel stemcell-based tissue engineering strategy for customizedand functional craniofacial bone regeneration. Given theunique ontogenetical and cell biological properties ofperinatal stem cells, emerging evidence has suggestedthese extraembryonic tissue-derived stem cells to be apromising cell source for extensive use in regenerativemedicine and tissue engineering. In this review, wesummarize the current achievements and obstaclesin stem cell-based craniofacial bone regeneration andsubsequently we address the characteristics of varioustypes of perinatal stem cells and their novel applicationin tissue engineering of craniofacial bone. We proposethe promising feasibility and scope of perinatal stemcell-based craniofacial bone tissue engineering for futureclinical application.
基金
National Natural Science Foundation of China,No.81271122 and No.81371122
Shanghai Leading Academic Discipline Project,No.S30206
