摘要
目的:探讨盐酸托莫西汀治疗儿童注意缺陷多动障碍(ADHD)的疗效和安全性。方法:计算机检索相关医学数据库,采用Meta分析对7项盐酸托莫西汀与安慰剂对比治疗ADHD对照研究的文献进行分析。结果:本研究纳入7篇文献,均为国外文献(Jadad评分≥3分);样本含量为1304例;Meta分析结果显示,治疗后盐酸托莫西汀组的注意缺陷/多动评定量表(ADHDRS)总分值[MD=-5.86,95%CI(-7.73,-3.99),P<0.00001]、ADHD-RS多动/冲动分量表分值[MD=-2.64,95%CI(-3.75,-1.52),P<0.00001]、ADHD-RS注意缺陷分量表分值[MD=-2.35,95%CI(-3.87,-0.83),P<0.00001]改善均显著优于对照组,两组比较有显著性差异;盐酸托莫西汀组患儿比对照组更容易发生腹痛、恶心、呕吐、嗜睡和食欲减退等不良反应(P<0.05)。结论:盐酸托莫西汀治疗儿童ADHD具有良好的疗效,可显著改善儿童ADHD的多动/冲动以及注意缺陷,但应注意其不良反应。
Objective： To assess the efficacy and safety of atomoxetine hydrochloride in the treatment of attention deficit hyperactivity disorder（ ADHD）. Methods： 7 comparative studies of tomoxetine hydrochloride in the treatment of ADHD were analyzed by Metaanalysis. Results： A total of 7 RCTs were included. The sample size was 1304 patients. Results of Meta-analysis showed that the improvement of ADHD-RS[MD =- 5. 86,95% CI（- 7. 73,- 3. 99）,P〈0. 00001 ]、ADHD-RS hyperactivity / impulsive[MD =- 2. 64,95% CI（- 3. 75,- 1. 52）,P〈0. 00001],ADHD-RS inattention[MD =- 2. 35,95% CI（- 3. 87,- 0. 83）,P〈0. 00001]in atomoxetine hydrochloride group were significantly greater than in control group. The incidence of abdominal pain,nausea,somnolence,decreased appetite and vomiting in atomoxetine group were higher than in control group（ P〈0. 05）. Conclusion： Atomoxetine is effective in the treatment of children with ADHD and can improve hyperactivity / impulsivity and attention deficit in children with ADHD. But the side effects of them should be considered.
出处
《中国药物评价》
2015年第1期50-54,共5页
Chinese Journal of Drug Evaluation
关键词
盐酸托莫西汀
儿童
注意缺陷多动障碍
META分析
Atomoxetine hydrochloride
Children
Attention deficit hyperactivity disorder
Meta-analysis
