摘要
目的：探讨甲氨蝶呤联合米非司酮治疗异位妊娠的临床护理措施。方法对128例异位妊娠患者行甲氨蝶呤联合米非司酮药物保守治疗，测定患者血β-人绒毛膜促性腺激素（HCG）水平，B超检查妊娠包块大小，用药过程中给予心理、饮食和日常活动、病情观察、药物不良反应等综合护理，并对患者进行出院指导。结果128例患者中，121例治疗成功，成功率为94．5％。治疗后1周与治疗前相比，患者血β-HCG水平和异位妊娠包块直径均下降，差异有统计学意义（ t值分别为33．2，8．9；P ＜0．05）；治疗后2，3，4周，患者血β-HCG水平低于治疗后1周，差异有统计学意义（t值分别为64．2，78．3，105．9；P＜0．05）；治疗后2，3，4周，患者包块直径小于治疗后1周，差异有统计学意义（t值分别为6．4，7．5，8．3；P＜0．05）。治疗过程中有5例（3．9％）患者出现胃肠道反应，分别有3例（2．3％）患者转氨酶轻度升高与白细胞减少，分别有2例（1．6％）患者出现口腔溃疡与骨髓抑制，给予相应处理后均恢复正常。结论甲氨蝶呤联合米非司酮保守治疗异位妊娠时，应给予患者积极的心理护理，加强临床护理，密切观察患者病情变化，以促进患者康复。
Objective To explore the clinical nursing of Methotrexate combined with Mifepristone in patients with ectopic gestation .Methods Totals of 128 patients with ectopic gestation were treated by Methotrexate combined with Mifepristone , and blood β-HCG level and lump diameter size were measured .The patients were given comprehensive nursing including psychology , diet and daily activities , disease observation , drug adverse reaction and discharge guidance .Results The rate of successful treatment was 94.5%（121/128）.The level of blood β-HCG and diameter of lump after 1 week were significantly smaller than those before the treatment （t=33.2,8.9, respectively;P〈0.05）.The level of blood β-HCG after 2,3,4 weeks were significantly lower than those after 1 week （t=64.2,78.3,105.9, respectively;P〈0.05）.And the diameter of lump after 2,3,4 weeks were significantly smaller than those after 1 week （t=6.4,7.5,8.3, respectively;P〈0.05）.Five patients （3.9%） had gastrointestinal reaction, three patients （2.3%） had slightly elevation of transaminase and leucopenia , two patients （ 1.6%） had oral ulcer and bone marrow suppression .Those symptoms were disappeared after treatment .Conclusions During the treatment of ectopic pregnancy , patients should be given positive psychological care , close clinical nursing and disease observation to promote the rehabilitation of patients .
出处
《中华现代护理杂志》
2015年第6期697-700,共4页
Chinese Journal of Modern Nursing
关键词
妊娠
异位
甲氨蝶呤
米非司酮
护理
Ectopic gestation
Methotrexate
Mifepristone
Nursing care
