摘要
目的：探讨急性冠状动脉综合征（ACS）经皮冠状动脉介入治疗（PCI）术前与术后患者炎性标记物：白细胞介素-6受体（IL-6R）和金属肽酶含血小板反应蛋白基元-1（ADAMTS-1）及氧化型低密度脂蛋白（ox-LDL）水平的变化及意义。方法选取 ACS 患者149例，其中急诊 PCI 急性心肌梗死（AMI）39例，PCI 不稳定型心绞痛（UA）42例；非 PCI 患者 AMI 32例，UA 36例。冠状动脉造影检查证实冠脉无狭窄对照组56例。所有研究对象入院时采静脉血，ACS 入院12小时后再次采静脉血，应用酶联免疫吸附试验（ELISA）法检测外周血 IL-6R、ADAMTS-1及 ox-LDL 水平。结果入院时 PCI AMI 组、PCI UA 组、AMI 组及 UA 组 IL-6R、ADAMTS-1及 ox-LDL 血清水平均高于对照组，差异有统计学意义（P ＜0．05）。入院时 PCI AMI 组及 AMI 组 ox-LDL 血清水平高于 PCI UA组、UA 组，差异有统计学意义（P ＜0．05）。入院12小时后 PCI AMI 组、PCI UA 组 IL-6R、ADAMTS-1水平均较入院时升高，差异有统计学意义（P ＜0．05）；而入院12小时后 AMI 组、UA 组 IL-6R、ADAMTS-1水平较入院时比较差异无统计学意义（P ＞0．05）。结论IL-6R、ADAMTS-1是 ACS 炎症反应的重要标志，ACS 经皮冠状动脉介入治疗术后炎症反应增加。
Objective To investigate the changes and significance of inflammatory markers：interleu-kin 6 receptor（IL-6R）,adisintegrin and metalloprotease with thrombospongdin type 1 motifs（ADAMTS-1）, oxidized low density lipoprotein（ox-LDL）preoperative and postoperative of percutaneous coronary inter-vention（PCI）in patients of acute coronary syndrome（ACS）.Methods 149 ACS patients were admitted, including 39 cases of acute myocardial infarction（AMI）and 42 unstable angina （UA）patients underwent PCI,32 cases of AMI and 36 UA patients without PCI.56 cases with no coronary artery stenosis were selected as a control group.Venous blood were collected at the time of admission,and will be collected again after 12 h in the ACS group,then detected the levels of IL-6R,ADAMTS-1 and ox-LDL of all the patients.Results The serum IL-6R,ADAMTS-1 and ox-LDL levels of group PCI-AMI,PCI-UA, no-PCI-AMI no-PCI-UA group were significantly higher than that of normal control group,the difference was statistically significant（P 〈0.05）.The serum ox-LDL level of group PCI-AMI and no-PCI-AMI was significantly higher than that of PCI-UA and no-PCI-UA group（P 〈0.05）;The serum IL-6R,ADAMTS-1 in group PCI-AMI and PCI-UA after 12 h increased compared with preoperative,the difference was statis-tically significant（P 〈0.05）.The serum IL-6R,ADAMTS-1 after 12h had no statistical difference com-pared with the time of admission in group no-PCI-AMI and no-PCI-UA（P 〉0.05）.Conclusion IL-6R and ADAMTS-1 are important symbols of inflammatory and the inflammatory levels increase after PCI in patients of ACS.
出处
《临床内科杂志》
CAS
2015年第3期178-180,共3页
Journal of Clinical Internal Medicine
基金
张家口市2013年科学技术研究与发展指令计划项目（1311055D-3）
