摘要
目的 :探讨血管内皮生长因子 (VEGF)与肿瘤内微血管形成的关系 ,以及微血管密度 (MVD)与乳腺癌淋巴结转移和预后的关系。方法 :采用免疫组化 S- P法对 4 0例人乳腺浸润性导管癌组织中的 VEGF和 MVD进行检测。结果 :VEGF阳性者 MVD值显著高于阴性者 ,VEGF表达和MVD与乳腺癌淋巴结转移关系密切。结论 :VEGF与乳腺癌血管生成密切相关 ,VEGF和 MVD表达的增高对乳腺癌淋巴结转移有促进作用 ,MVD和
Objective:To investigate the relationship between vascular endothelial growth factor(VEGF) and angiogenesis,between microvascular density(MVD) and lymph node metastasis and prognosis of breast carcinoma.Methods:The VEGF protein expressions and MVD were determined by immunohistochemical S P technique in the tissues of breast invasive ductal carcinoma of 40 cases.Results:MVD was significantly higher in VEGF positive breast carcinoma than in VEGF negative breast carcinoma, VEGF protein expression and MVD correlated significantly with lymph node metastasis.Conclusion:VEGF is highly related to promoting angiogenesis of breast carcinoma.The increase of VEGF and MVD may promote lymph node metastasis.MVD and VEGF were regarded as prodictors for the biological behariors of breast cavcinoma.
出处
《肿瘤研究与临床》
CAS
2002年第4期237-238,共2页
Cancer Research and Clinic
