摘要
目的探讨小剂量口服克拉霉素抑制慢性阻塞性肺疾病(COPD)急性发作的效果。方法 120例COPD患者随机分为观察组与对照组,对照组采用常规疗法治疗COPD,观察组加用小剂量口服克拉霉素治疗,12周后统计两组患者COPD急性发作情况、肺功能变化、生活质量变化及不良反应发生情况。结果在治疗研究的12周中,观察组COPD总急性发作人数、2次以上发作人数及严重发作致住院人数均少于对照组(P<0.05);治疗前,两组FEV1%比较差异无统计学意义(P>0.05),治疗12周后,观察组FEV1%明显高于对照组(P<0.05);治疗前,两组SGRQ评分中呼吸症状、疾病影响、活动能力评分及总分比较差异无统计学意义(P>0.05),治疗12周后,观察组呼吸症状、疾病影响、活动能力评分及总分均低于对照组(P<0.05)。治疗前后两组患者肝肾功能指标均正常,观察组中发生恶心2例(3.33%)。呕吐1例(1.67%),纳差1例(1.67%);对照组中发生恶心4例(6.67%),纳差2例(3.33%)两组不良反应发生总例数比较差异无统计学意义(P>0.05)。结论小剂量克拉霉素疗法对急性发作的COPD可起到减少急性发作次数,缓解急性发作严重程度的效果;而对于发作间期的COPD,可明显改善肺功能,提高生活质量,且无明显不良反应。
Objective To discuss the clinical effects of low dose oral clarithromycin on depressing acute attack of chronic obstructive pulmonary diseases（COPD）.Methods A total of 120 patients suffered COPD were divided into two groups randomly：observation group and control group.Patients in control group were treated routinely,and patients in observation group were treated with clarithromycin additionally,and the acute attack,cchange of lung function /quality of life and adverse drug reaction of the two groups were compared after 12 weeks of treatment.Results During the 12 weeks of treatment,the number of patients in observation group who suffered acute attack of COPD,more than 2 times of acute attack and serious attack were lower than those of control group（P 0.05）;there was no in significant difference in FEV1%before treatment between the two groups（P 0.05）,and the FEVl%of observation group was higher than that of control group after treatment（P 0.05）;there was no significant difference in the score of SGRQ,including respiratory symptom,sickness impact and activity of daily living between the two groups before treatment（P 0.05）,and the scores of observation group were lower than those of control group after treatment（P 0.05）;the hepatorenal function of two groups were normal before and after treatment,and during the treatment,there were 2（3.33%）patients felt nausea,1（1.67%） felt vomit and 1（1.67%） felt inappetence in observation group,and 4（6.67%） nausea,2（3.33%） inappetence in control group,but the total number of patients who suffered adverse drug reaction had no significant difference between the two groups（P 0.05）.Conclusion The therapy of low dose oral clarithromycin can decrease the acute attack of COPD,relieve severity degree of attack,and improve lung function,increase the quality of life,but leave no significant adverse drug reaction.
出处
《实用药物与临床》
CAS
2015年第3期348-351,共4页
Practical Pharmacy and Clinical Remedies
