摘要
目的评估使用雷公藤(Tw HF)治疗Ig A肾病的有效性及安全性。方法使用计算机对Embase、Pubmed、Cochrane图书馆临床对照试验注册数据库、CNKI、CBM、万方数据库、维普等数据库进行检索。从中纳入所有的随机对照试验(RCT)及相关对照试验。采用缓解率、24 h尿蛋白定量(24h UP)、血肌酐(Scr)、不良事件等指标进行评价。结果最终纳入6篇中文文献,发表时间在2001-2013年,共350例患者进入本系统评价,用Meta分析或描述性分析处理数据。1治疗组治疗6个月完全缓解率高于对照组(RR=2.17,95%CI[1.42,3.30]),总缓解率高于对照组(P<0.05)。224h UP:6个月时治疗组低于对照组(WMD=-0.47,95%CI[-0.64,-0.24])。3Scr:治疗组与对照组比较差异无统计学意义(P>0.05)。4不良反应:治疗组发生月经异常为对照组的9.9倍(RR=9.90,95%CI[1.62,60.35]),但总体不良反应与纳入文献中的其他药物对照无明显差异。结论雷公藤治疗Ig A肾病总缓解率及完全缓解率优于对照,可减低24 h尿蛋白排泄,但易导致月经异常。
Objective To assess the efficacy and security of tripterygium wilfordii Hook F for IgA nephropathy. Methods Embase,Pubmed,the Cochrane Controlled Trials Register Database,CNKI,CBM,WANFANG and VIP database were searched. Two reviewers independently assessed and extracted information such as remission rate,24 h UP,Scr and adverse event from RCT. Results A total of 6 RCT Chinese literatures were cited in this essay,which were published from 2001 to 2013,350 patients were evaluated. 1The result in terms of treatment group showed a significant higher complete remission rate（ RR = 2. 17,95% CI [1. 42,3. 30]） than control group after six month,and the total remission rate（P〈0. 05） was higher too. 224 h UP： treatment group showed a significant lower level of 24 h UP in six month,compared with control group（ WM D =-0. 47,95% CI [-0. 64,-0. 24]）. 3 Scr： there was no significant difference in Scr between treatment group and control group（P〈0. 05）. 4 Adverse reaction： the happen of abnormal menstruation cases in the treatment group was 9. 9 times of control group（ RR = 9. 90,95% CI [1. 62,60. 35]）. Conclusion The total remission rate and complete remission rate of IgA nephropathy patients treated with TwHF is higher than that of control group,but the TwHF could induce abnormal menstruation.
出处
《实用药物与临床》
CAS
2015年第3期293-297,共5页
Practical Pharmacy and Clinical Remedies
基金
成都医学院科研项目(CYFY12DL-004)
关键词
雷公藤
IG
A肾病
系统评价
META分析
Tripterygium
Immunoglobulin A nephropathy
Systematic review
Meta-analysis
