摘要
目的探讨类风湿关节炎(RA)患者出现膝冷痛的临床特点。方法收集我院诊治的以膝关节不适为主诉的RA患者60例,其中伴有膝冷痛者30例,收集其疾病活动性评分28(DAS28)、膝冷痛评分,行远红外断层扫描成像技术(TTM)测量膝关节TTM值,同时检测血清缺氧诱导因子-1α(HIF-1α)、血沉(ESR)、C反应蛋白(CRP),比较两组之间的差异。结果膝冷痛组与无膝冷痛组在病程(t=5.932,P=0.000)、DAS28评分(t=2.716,P=0.007)、膝前TTM记录值(t=7.731,P=0.000)、ΔTTM记录值(t=14.295,P=0.000)、CRP(t=5.684,P=0.000)、ESR(t=4.506,P=0.000)、HIF-1α(t=4.817,P=0.000)的差异有统计学意义。结论膝冷痛作为中晚期RA患者的主诉之一,具有长病程、低疾病活动度、低炎症水平、低HIF-1α的特点。
Objective To investigate the clinical characteristic of rheumatoid arthritis associated with cold pattern knee joint pain.Methods The study enrolled 60 patients of RA with the complaint of knee pain,30 cases with cold pattern and 30 cases without cold pattern.The clinical symptoms,DAS28 score,cold knee score were collected,and serum hypoxia inducible factor-1α（HIF-1α）erythrocyte sedimentation rate（ESR）,C-reactive protein（CRP）and thermal texture maps（TTM）of knee temperature were measured.The difference between two groups was compared to analyze the clinical characteristics of RA with cold pattern knee pain Results There were differences between the two groups in the course（t=5.932,P =0.000）,DAS28score（t=2.716,P=0.007）,knee TTM（t=7.731,P=0.000）,absolute difference of thermal texture maps between popliteal fossia and front district in knee（ΔTTM）（t=14.295,P=0.000）,CRP（t=5.684,P=0.000）,ESR（t=4.506,P=0.000）,HIF-1α（t=4.817,P =0.000）.Conclusion RA patients with cold pattern knee pain show the clinical characteristics with longer course of disease,lower level of local inflammation,lower disease activity.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2015年第2期293-295,158,共3页
Journal of Sichuan University(Medical Sciences)
基金
四川省卫生厅资助课题(No.120160)
四川省骨科医院院管课题(No.2011014
No.2013008)资助
关键词
缺氧诱导因子-1Α
类风湿关节炎
膝冷痛
远红外成像系统
Hypoxia-inducible factor-1α
Rheumatoid arthritis
Knee pain because of cold pattern
Thermal texture maps
