摘要
[目的]比较特利加压素与奥曲肽治疗肝硬化上消化道出血的效果与安全性。[方法]入选86例肝硬化胃底食管静脉曲张出血患者,以入院序号单、双数分为2组,单数患者为A组,给予特利加压素治疗;双数患者为B组,给予奥曲肽治疗,记录2组患者出血停止时间、平均输血量及不良反应,评价其效果和安全性。[结果]A组患者平均止血时间(10.63±2.87)h,明显短于B组[(14.19±3.07)h],P<0.05;A组平均输血量(4.1±0.6)U,少于B组[(5.2±1.7)U],P<0.01;治疗后72h,A组平均血红蛋白(95.6±21.4)g/L、血细胞比容(35.4±6.2)%,均明显高于B组[(90.1±18.6)g/L、(30.5±5.0)%],P<0.05;A组总有效率为83.72%、不良反应发生率为4.65%,B组总有效率为72.09%、不良反应发生率为13.95%,2组疗效及不良反应发生率比较均差异有统计学意义(P<0.05)。[结论]特利加压素治疗肝硬化上消化道出血的疗效好,安全性高。
[Objective]To compare the the effect and safety of the terlipressin and the octreotide in treatment of upper gastrointestinal hemorrhage induced by liver cirrhosis.[Methods]During the period of 2013March-2014 March,Eighty-six patients with upper gastrointestinal hemorrhage induced by liver cirrhosis in our hospital were divided into two groups.Patients in group A were given the terlipressin;the patients in group B were treated by octreotide.The time of bleeding stop,blood transfusion volume,average adverse reactions were recorded and the efficacy and safety were evaluated.[Results]The average hemostasis time ingroup A was 10.63±2.87 h,which was significantly shorter than that in group B.The average volume of blood transfusion were（4.1±0.6）U in group A,which was less than that in group B（P〈0.05）.Seventytwo hours after treatment,the average hemoglobin g/L（95.6±21.4）and hematocrit（35.4±6.2）% in group A was significantly higher than those in B group（P〈0.05）;The total effective rate in group A was83.72%,which was significantly higher than that in group B（72.09%）（P〈0.05）.The adverse reaction rate in group A was 4.65%,which was significantly lower than that in group（P〈0.05）.[Conclusion]Terlipressin has good curative effect,and high safety.
出处
《临床消化病杂志》
2015年第1期23-26,共4页
Chinese Journal of Clinical Gastroenterology
关键词
肝硬化上消化道出血
特利加压素
奥曲肽
效果
安全性
liver cirrhosis with upper gastrointestinal hemorrhage
terlipressin
octreotide
efficacy
safety
