摘要
目的探讨多巴胺联合去甲肾上腺素治疗心源性休克的疗效及安全性。方法 191例心源性休克患者入选本次研究,联合用药组(n=100)应用多巴胺联合去甲肾上腺素,多巴胺组(n=91)给予多巴胺药物治疗。密切注意2组患者在治疗前后收缩压、舒张压、肌酐、每小时尿量、血浆β型脑钠肽(BNP)、左室射血分数(LVEF)等各项指标的变化和临床改善情况。结果治疗7 d后,联合用药组有较高的治疗显效率(P=0.099)和较低的死亡率(P=0.069),但差异无统计学意义。联合用药组治疗后舒张压水平较高(P=0.012)。恶性心律失常导致血流动力学不稳定的事件发生率,差异无统计学意义(P=0.710)。结论与单纯多巴胺比较,多巴胺联合去甲肾上腺素治疗心源性休克有很好的疗效和安全性,并且有降低总死亡率的趋势。
Objective To evaluate the safety and efficiency of combination of dopamine and noradrenaline for the treatment of cardiogenic shock. Methods Clinical data of 191 patients with cardiogenic shock were collected,100 patients receiving combination of dopamine and noradrenaline, while 91 patients receiving solo Dopamine treatment. The systolic pressure, diastolic pressure,creatinine, urine of every hour, Brain Natriuretic Peptide （BNP）, left ventricular ejection fraction （LVEF） changes and clinical improvement of two groups were observed closely before and after treatment.Results Compared with Dopamine group, the DBP was significantly higher （P=0.012） and mortality rate was not significantly decreased （P=0.069） in patients with combination of dopamine and noradrenaline. Arrhythmic events rare was not different between groups （P=0.710）. Conclusion In patients with cardiogenic shock, combination of dopamine and noradrenaline was safe and showed a non-significant low mortality rate.
出处
《当代医学》
2015年第8期139-140,共2页
Contemporary Medicine
